Acute Porphyria Drug Database

C01CA24 - Epinephrine
Not porphyrinogenic
NP

Rationale
Endogenous catecholamine. Non-CYP dependent metabolism. No data pointing to CYP-interaction.
Chemical description
Endogenous catecholamine.
Therapeutic characteristics
Catecholamine used in asthma bronchiale, cardiac arrest, hypersensitivity reactions. Parenterally administered in 0.3-1 mg dose.
Metabolism and pharmacokinetics
Epinephrine (adrenalin) is an endogenous compound. It is very rapidly inactivated by processes which include uptake into adrenergic neurones, diffusion, and enzymatic degradation in the liver and body tissues. Metabolism involves monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT).
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.

References

  1. Scientific articles
  2. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53. #1016
  3. Drug reference publications
  4. Sweetman SC, editor. Martindale: The complete drug reference. Adrenaline. Pharmaceutical Press 2009. #1017

Similar drugs
Explore alternative drugs in similar therapeutic classes C01C / C01CA or go back.

 
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