Acute Porphyria Drug Database

C03CA01 - Furosemide
Propably not porphyrinogenic
PNP

Rationale
(CAVE: under revision)Sulfonamide derivative. Conflicting references, but non-metabolism as well as clinical observations point to non-porphyrinogenicity.
Chemical description
Sulfonamide derivative.
Therapeutic characteristics
Shortacting loop-diuretic.
Metabolism and pharmacokinetics
Primarily excreted by filtration and secretion as unchanged drug. Some liver metabolism may occur. The glucuronide is the most significant metabolite. Non-porphyrinogenic metabolism.
Personal communication
Thunell, patient report (n=2): tolerated. Andersson, patient report (n=9): tolerated.
Published experience
Two non-English publications seem to involve uneventful exposure of two acute porphyria patients (Lopes Montes 2004, Moeschlin 1975).
IPNet drug reports
Uneventful use reported in 47 patients with acute porphyria.

References

  1. Scientific articles
  2. Moeschlin S, 1975. PMID 56031. PMID 56031. #4397
  3. Lopes Montes A et al. 2004. PMID 15219077. PMID 15219077. #4396

Similar drugs
Explore alternative drugs in similar therapeutic classes C03C / C03CA or go back.

 
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