Limitations: This safety classification applies only to preparations containing a combination of the two drugs metoprolol and felodipine. The same ATC-code (C07F B02) can in some countries be used for different combinations of metoprolol and other drugs, which in theory may be porphyrinogenic. Please refer to the classification and monograph of each individual substance. If the combination contains a substance which is not classified (NC) or has been classified as porphyrinogenic (PRP or P), the safety classification of such a combination as PNP is no longer valid. Combination products which contains the two substances metoprolol (ATC code: C07A B02) and felodipine (ATC code: C08C A02) are safety classified as Probably not porphyrinogenic (PNP). Metoprolol is safety classified as Not porphyrinogenic (NP) while felodipine is classified as Probably not porphyrinogenic (PNP). The classification of this combination is according to the most porphyrinogenic of the two substances. For more details please refer to the monographs of the two substances.