A03BB01 - Butylscopolamine |
Propably not porphyrinogenic |
PNP |
Rationale
Non-CYP metabolism. No data pointing to clinical CYP induction or inhibition.
Without references warned against in Martindale, however no other reports of observed porphyrogenicity are present.
Chemical description
Butylscopolamine is a quarternary ammonium compound.
Therapeutic characteristics
butylscopolamine is an antispasmodic drug used in the treatment of gastrointestinal, bile duct, renal and urogenital spastic conditions, often together with opioid analgesics. It is also used prior to diagnostic procedures such as X-ray and gastro-duodenal endoscopy. It is administered as a subcutaneous, intramuscular or slow intravenous injection. It can also be administered orally.
Metabolism and pharmacokinetics
Given orally the bioavailability of butylscopolamine is very low because of its very high affinity to gastrointestinal muscarin and nicotine receptors. Even in the high systemic concentrations after parenteral administratration, the majority of the dose may conceivably be trapped by tissue receptors prior to liver passage. Low degree of binding to plasma proteins. The main metabolic pathway of butylscopolamine is hydrolytic cleavage of the ester bond. The metabolites are excreted by the kidneys. 50 % is excreted as unchanged drug in urine. (Tytgat 2007).
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria. Also uneventful use of butylscopolamine in combination with analgesics (ATC A03D B04) has been reported in 1 patient with acute porphyria.
References
- Scientific articles
- Tytgat G. N. Hyoscine Butylbromide, a review of its use in the treatment of abdominal cramping and pain. Drugs 2007; 67 (9): 1343-1357 PMID 17547475. #4340
- Drug reference publications
- Sweetman SC, editor. Martindale: The complete drug reference. Butylscopolamine. Pharmaceutical Press 2009. #1065
- Summary of Product Characteristics
- Norwegian medicines agency. Summary of Product Characteristics (SPC). Buscopan. #1064
- The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Buscopan. #1066
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