No data pointing to CYP-interaction. Two references authorised / use with care.

(To be edited, initial data ST OCT 04) Used in hypertrophic prostatic disease, 2-5 mg/d. Quinazoline derivative with selective effect on alpha-1-receptors in the bladder, giving rise to relaxation. Metabolized in the liver by hydrolysis and demethylation. No data pointing to CYP-interaction. South African list: use with care. French list: authorized

Uneventful use reported in 3 patients with acute porphyria.