J01AA01 - Demeclocycline |
Propably not porphyrinogenic |
PNP |
Rationale
Demeclocycline is not listed as an inducer or as a mechanism based inhibitor of any CYP enzymes. It is excreted unchanged in urine and faeces.
Chemical description
Demeclocycline is a tetracycline broadspectrum antibiotic.
Therapeutic characteristics
Demecloclycline is used for the treatment of infections caused by tetracycline-sensitive organisms. It is also used in the treatment of chronic hyponatraemia associated with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) secondary to malignant disease. It is administered orally.
Metabolism and pharmacokinetics
Demeclocycline is not metabolized, but is excreted unchanged in urine and faeces (Agwuh 2006). It has a half-life of 12 hours (SPC).
Demeclcycline is not listed as an inducer or as a mechanism based inhibitor of CYP enzymes, and no CYP related drug-drug interactions are described (Micromedex, Lexi-Interact).
References
- Scientific articles
- Agwuh KN, MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006 Aug;58(2):256-65. PMID 16816396. #1599
- Drug interaction databases
- Lexi-Interact, via UpToDate. #1152
- Micromedex® 2.0 (online). Drug Interactions. (03.06.2016). #1600
- Summary of Product Characteristics
- The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Demeclocycline Hydrochloride. #1601
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