Acute Porphyria Drug Database

J01DB03 - Cefalotin
Propably not porphyrinogenic
PNP

Rationale
Cefalotin has no potentially porphyrinogenic pharmacokinetic or pharmacodynamic properties.
Chemical description
Beta-lactam antibiotic.
Therapeutic characteristics
Cefalotin is a semi synthetic first generation parental cephalosporin with a broad spectrum of antibiotic activity. It is used in the treatment of infections and for surgical infection prophylaxis.
Metabolism and pharmacokinetics
Cefalotin is partly metabolized to a less active desacetyl metabolite. 50-75% of the drug is eliminated unchanged in the urine. It has a half-life of 30-50 minutes. Not suspected to have any effect on the activities of cytochrome P450 enzymes.

References

  1. Drug reference publications
  2. DrugBank. Cefalotin. #1630
  3. Drug interaction databases
  4. Lexicomp Online. Martindale: The Complete Drug Reference. Cefalotin Sodium. (27.07.2010) #1631
  5. Summary of Product Characteristics
  6. Norwegian medicines agency. Summary of Product Characteristics (SPC). Keflin. #1632

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