Not metabolised. No data pointing to CYP interaction. Conflicting references.

Perorally used cephalosporin (500 mg x 2) antibiotic used in uncomplicated urinary tract infections, skin and soft tissue infections and in pharyngotonsillitis where penicillin V has shown to be without effect. Only about 2 % is metabolized by decarbamylation, the drug thus mainly excreted in unchanged form by the kidneys. No data pointing to CYP-affinity. South African list: use with caution . French list: unsafe. Andersson:used occasionally without side effects.Said by one patient, however, to have triggered symtoms.

Uneventful use reported in 2 patients with acute porphyria.