Competitive CYP-inhibitor. Some clinical experience of tolerance. Conflicting references.

(To be edited, initial data ST OCT 04) Quinolone antibiotic. About 50% of the dose is excreted in unchanged form by the kidneys. Four metabolites are observed. Competetive inhibitor of several CYPs, possibly also at the transcrptional level. Some interference with fluorimetric determination of urinary porphyrins, reported. South African list: use with extreme caution only. French list: use. Australian list: safe. Thunell, patient enquiry: used without ill effects (n=1). Andersson: Used in some patients and well tolerated. See also: Schoenfelt and Mamet. Interference of ofloxacin with determination of urinary porphyrins. Clin Chem 1994, 40; 417-19.

Uneventful use reported in 32 patients with acute porphyria.