Acute Porphyria Drug Database

J01MA06 - Norfloxacin
Propably not porphyrinogenic
PNP

Rationale
CYP 3A4-inhibitor. Conflicting references but some clinical experience of non-porphyrinogenicity.
Chemical description
Quinolone antibiotic. Some metabolism takes place and several metabolites have been identified in urine. About 30% is excreted in urine in unchanged form within 24 hours, while the same amount is recoverd in faeces. Inhibitor of CYP 3A4. Some interference with fluorimetric determination of urinary porphyrins, reported. Australian list: safe. South African list: use with extreme caution only. French list: use. S Thunell, patient inquiry: well tolerated(n=4). Andersson:
IPNet drug reports
Uneventful use reported in 18 patients with acute porphyria.

Similar drugs
Explore alternative drugs in similar therapeutic classes J01M / J01MA or go back.

 
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