J05AB14 - Valganciclovir |
Not porphyrinogenic |
NP |
Rationale
Prodrug converted by intestinal and hepatic esterases to ganciclovir, which is not further metabolised.
Chemical description
L-valinate ester of the antiviral ganciclovir used to prevent CMV-infection in CMV-negative patients receiving organ transpalantate from CMV positive donor. Rapidly and completely metabolized by intestinal and hepatic esterases to ganciclovir.
IPNet drug reports
Uneventful use reported in 2 patients with acute porphyria.
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