Probably insignificant systemic exposure.

(To be edited, initial data ST OCT 04) Contact laxative; enterotablets 5-10 mg/d or supp.10 mg/d. Diphenyl pyridine derivative hydrolyzed in the intestine to desaetylbisacodyl, which is absorbed and excreted in urine and bile as glucuronide. A diphenol is formed in colon which stimulates motility. Only minute amounts reach the system. South African list: use with care

Uneventful use reported in 2 patients with acute porphyria.