Probably insignificant systemic effects outside bone tissue. Occasional observation of tolerance.

(To be edited, initial data ST OCT 04) Pyridinyl biphosphonate used in menopausal osteoporosis. Binds to bone tissue where it inhibits osteoclastic activity. Thunell; observed to be tolerated (n=1)

Uneventful use reported in 5 patients with acute porphyria.