Opioid. References state non-porphyrinogenicity.

(To be edited, initial data ST OCT 04) Opioid analgesic metabolized to a large extent and excreted in urine in conjugated form. Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.Biochem Biophys Acta 543:313, 1978: safe. Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: probably safe.

Uneventful use reported in 1 patient with acute porphyria.