Limitations: This safety classification applies only to preparations containing a combination of the two drugs codeine and paracetamol, both of which are classified PNP. This ATC-code (N02AA59) can in some countries be used for different combinations of codeine and other drugs which in theory may be porphyrinogenic. Please refer to the classification and monograph of each individual substance. If the combination contains a substance which is not classified (NC) or has been classified as porphyrinogenic (PRP or P), the safety classification of such a combination as PNP is no longer valid. To read the full evaluation of the drugs under this ATC-kode please refer to the induvidual monographs of codeine (R05DA04) and paracetamol (N02BE01).

Uneventful use reported in 61 patients with acute porphyria.