Hydromorphone: Opioid. References consider it safe/probably safe. Atropine: No data pointing to CYP-interaction Several references consider it safe.

(To be edited, initial data ST OCT 04) Hydromorphone: opioid analgesic metabolized to a large extent and excreted in urine in conjugated form. Atropine:Tertiary amine spasmolytic. No data pointing to CYP-interation. Hydromorphone: Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: probably safe Atropine: MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe Australian list: safe. South African list: use . French list: use. Kalman, Bonkovsky: belived to be safe. Moore MR, Hift RJ, Drugs in the acute porphyrias - toxicogenetic diseases. Cell Mol Biol 43:89, 1997: safe Eales L: Porphyria and the dangerous life-threatening drugs. S Afr. med J 56:914, 1979: safe