Insignificant CYP 2C9 metabolism. Repeatedly experienced to be safe in acute porphyria. Several references state non-porphyrinogenicity.

(To be edited, initial data ST OCT 04) Light analgesic, inhibitor of prostaglandin synthesis. Metabolized by conjugation with glycine. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use EPI-list: safe South African list: use French list: use Kalman, Bonkovsky: safe Merck Index: safe Eales L: Porphyria and the dangerous life-threatening drugs. S Afr Med J 56:914,1979: safe Swedish experience (n=32): tolerated.

Uneventful use reported in 90 patients with acute porphyria.