A07DA03 - Loperamide |
Propably not porphyrinogenic |
PNP |
Rationale
Synthetic opiate, some systemic absorption takes place. Probably CYP-metabolised. No data pointing to CYP-induction. Two references state non-porphyrinogenicity.
Chemical description
Synthetic opiate used in diarrhoea. Metabolized by oxidative N-demethylation. No data given on CYP-interaction, South African list: use. French list: authorized
IPNet drug reports
Uneventful use reported in 17 patients with acute porphyria.
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