Synthetic opiate, some systemic absorption takes place. Probably CYP-metabolised. No data pointing to CYP-induction. Two references state non-porphyrinogenicity.

(To be edited, initial data ST OCT 04) Synthetic opiate used in diarrhoea. Metabolized by oxidative N-demethylation. No data given on CYP-interaction, South African list: use. French list: authorized

Uneventful use reported in 17 patients with acute porphyria.