Epinephrine (adrenaline) is an endogenous catecholamine with non-CYP dependent metabolism. There are no data pointing to CYP-interaction.

Endogenous catecholamine.

Epinephrine (adrenaline) is a catecholamine used in asthma bronchiale, cardiac arrest, hypersensitivity reactions. Parenterally administered in 0.3-1 mg dose.

Epinephrine (adrenalin) is an endogenous compound. It is very rapidly inactivated by processes which include uptake into adrenergic neurones, diffusion, and enzymatic degradation in the liver and body tissues. Metabolism involves monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT). As a result of enzymatic degradation in the gut and first-pass metabolism in the liver, adrenaline is almost totally inactive when given orally.

Uneventful use reported in 5 patients with acute porphyria, in combination with local anaesthetics.