Acute Porphyria Drug Database

A01AD01 - Epinephrine
Not porphyrinogenic
NP

Rationale
Epinephrine (adrenaline) is an endogenous catecholamine with non-CYP dependent metabolism. There are no data pointing to CYP-interaction.
Chemical description
Endogenous catecholamine.
Therapeutic characteristics
Epinephrine (adrenaline) is a catecholamine used in asthma bronchiale, cardiac arrest, hypersensitivity reactions. Parenterally administered in 0.3-1 mg dose.
Metabolism and pharmacokinetics
Epinephrine (adrenalin) is an endogenous compound. It is very rapidly inactivated by processes which include uptake into adrenergic neurones, diffusion, and enzymatic degradation in the liver and body tissues. Metabolism involves monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT). As a result of enzymatic degradation in the gut and first-pass metabolism in the liver, adrenaline is almost totally inactive when given orally.
IPNet drug reports
Uneventful use reported in 5 patients with acute porphyria, in combination with local anaesthetics.

References

  1. Scientific articles
  2. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53. #1016
  3. Drug reference publications
  4. Sweetman SC, editor. Martindale: The complete drug reference. Adrenaline. Pharmaceutical Press 2009. #1017

Similar drugs
Explore alternative drugs in similar therapeutic classes A01A / A01AD or go back.

 
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