Substrate for CYPs 3A4. Inhibitor of CYP 2C3.Inducer of CYP 3A5. Several references consider it safe.

(To be edited, initial data ST OCT 04) Glucocorticoid for local treatment of Mb Crohn. Biovailability 3-50%. Metabolized by CYPs 3A4. South African list: use. French list: authorized. Merck Index: safe Kahlman, Bonkowky: believed to be safe.

Uneventful use reported in 2 patients with acute porphyria.