Not significantly metabolised.

(To be edited, initial data ST OCT 04) Antibiotic used in acute treatment of Pneumocystis carnii- pneumonia (PCP) of moderate severity in patients that cannot tolerate trimethoprim - sulfamethoxazol. Admiistered as oral susspsion 1500 mg daily for 21 days Highly lipophilic substance with restricted bioavailability. Clinically efficient plasma concentration is 15 mg/ml. Excreted in unchanged form in stool. South African list: No data/avoid

Uneventful use reported in 4 patients with acute porphyria.