Inducer of CYP 3A5. Probably no significant systemic exposure. Several references stating non-porphyrinogenicity of glucocorticoids.

(To be edited, initial data ST OCT 04) Antiinflammatory halogenated glucocorticoide for local (nasal spray) treatment of allergic and vasomotor rhinitis. Low probability for systemic effects. EPI-list: safe. French list: authorized. South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncans Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

Uneventful use reported in 6 patients with acute porphyria.