Probably insignificant systemic exposure. Several references stating non-porphyrinogenicity of glucocorticoids.

(To be edited, initial data ST OCT 04) Glucocorticoide with strong antiinflammatory effect used in nasal spray in allergic and vasomotor rhinitis. The amount of budesonide in each dose is 50 - 100 µg. Systemic exposure 33%. Used in porphyria ward (Sweden). EPI-list: safe French list: authorized. South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe