Inducer of CYP 3A5. Probably insignificant absorption. Several references stating non-porphyrinogenicity of glucocorticoids.

(To be edited, initial data ST OCT 04) Halogenated corticosteroid in inhalation aerosol, used in treatment of asthma. Systemic exposure only of doses > 1 500 ug/24 h (adults) Used in porphyria ward (Sweden). glucocorticoids EPI-list: safe South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncans Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

Uneventful use reported in 12 patients with acute porphyria.