Opioid substrate for 2D6 and 3A4. Several references consider it safe for use.

(To be edited, initial data ST OCT 04) Opioide with analgetic and antitussive properties. Demetylated by CYP 2D6 and 3A4. Inhibitor of 2D6. EPI-list: safe South African list: use French list: authorized Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543:313, 1978: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

Uneventful use reported in 27 patients with acute porphyria.