Insignificant hepatic exposure.

(To be edited, initial data ST OCT 04) Eyedrops for treatment of glaucoma. Prostaglandin F2 alpha analogue, meablized in the same way as the endogenous prostaglandin by reduction of the 13-14 double bond, oxidation od the 15-hydroxyl group and beta-oxidative breaking of the upper side chain. Low systemic exposure of the free acid, plasma concentration < 25 pg/ml.

Uneventful use reported in 1 patient with acute porphyria.