V01AA02 - Grass Pollen |
Propably not porphyrinogenic |
PNP |
Rationale
Grass pollen extracts consists mainly of polypeptides and proteins that are not subject to liver metabolism or interaction with CYP enzymes.
Chemical description
Allergen extract, grass pollen. Contains polypeptides and proteins.
Therapeutic characteristics
Allergen extracts containing grass pollen are used in allergy immunotherapy, to desensitize people that have an allergy to grass pollen. It is administered as a sublingual tablet or as a subcutaneous injection. It may be used continuously throughout the season or for up to 3to 5 years for long term efficacy (SPC, Senna 2011).
Metabolism and pharmakokinetics
The grass pollen extract consist mainly of polypeptides and proteins, which are expected to be broken down to amino acids and small polypeptides in the lumen of the gastrointestinal tract and in tissues. It is not expected that the allergens is absorbed into the vascular system to any significant extent. No pharmacokinetic studies in animals or clinical studies have been conducted (EMEA, SPC).
References
- Scientific articles
- Senna GE, Calderon M, et al. Allergy immunotherapy tablet: Grazax for the treatment of grass pollen allergy. Expert Rev Clin Immunol. 2011 Jan;7(1):21-7. #2947
- Government bodies
- EMEA. Committee for Medicinal Products for Human Use (CHMP) and Efficacy Working Party (EWP): Guideline on the clinical development of products for specific immunotherapy for the treatment of allergic diseases; EMEA/CHMP/EWP/18504/ 2006. 2008. #4797
- Summary of Product Characteristics
- The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Grazax. (Last edition: November 2017). #2948
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