Naloxone is most probably not an inhibitor or an inducer of any major CYP enzymes. Several references consider it as safe. Risk for gastrointestinal adverse events in the form of nausea and vomiting motivates vigilance against insufficient intake of food, especially of carbohydrate.

Naloxone is an opioid antagonist.

Naloxone may be used for the complete or partial reversal of opioid depression, including mild to severe respiratory depression induced by natural and synthetic opioids. Very common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack is nausea. A common side effect is vomiting.

Naloxone hydrochloride is rapidly metabolised in the liver, mainly by conjugation with glucuronic acid, and excreted in urine. The half-life elimination is 1-1.5 hours. No drug-drug interactions with naloxone as a perpetrator regarding CYP enzymes are observed (Interaksjoner and Interaktionsdatabasen), which indicate that naloxone is not an inhibitor or inducer of CYP enzymes.

Naloxone is listed as safe/likely safe (Hunter 1999).