V08CA09 - Gadobutrol |
Not porphyrinogenic |
NP |
Rationale
Gadobutrol is not metabolised. It is excreted unchanged through the kidneys.
Chemical description
Gadobutrol is a nonionic gadolinium chelate.
Therapeutic characteristics
Gadobutrol is used as a magnetic resonance contrast medium. It is administered intravenously.
Hepatic exposure
Not significant.
Metabolism and pharmakokinetics
Gadobutrol is not metabolised and more than 90% of a dose is excreted in the urine within 12 hours.
References
- Drug reference publications
- Sweetman SC, editor. Martindale: The complete drug reference. Gadobutrol. Pharmaceutical Press 2009. #2970
- Summary of Product Characteristics
- Norwegian medicines agency. Summary of Product Characteristics (SPC). Gadovist. #2969
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