Acute Porphyria Drug Database

D11AX18 - Diclofenac
Propably not porphyrinogenic
PNP

Rationale
Diclofenac (ATC code: D11A X18) for topical administration is safety classified as Probably not porphyrinogenic because of minimal systemic exposure and because diclofenac for systemic use (ATC code: M01A B05) is classified as Probably not porphyrinogenic (PNP). For more details of the metabolism of diclofenac please refer to the monograph of diclofenac for systemic use (ATC code: M01A B05).
Metabolism and pharmacokinetics
Absorption after topical administration is < 1-12% (SPC).
IPNet drug reports
Uneventful use reported in 4 patients with acute porphyria.

References

  1. Summary of Product Characteristics
  2. Norwegian medicines agency. Summary of Product Characteristics (SPC). Solaraze. #1392

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