C01CA04 - Dopamine |
Not porphyrinogenic |
NP |
Rationale
Endogenous substance. Non-CYP metabolism. No data pointing to CYP-interaction.
Therapeutic characteristics
Endogenous signal substance liberating noradrenaline. Used in shock due to its inotropic effect on heart minute volume.
Metabolism and pharmakokinetics
Metabolized by monoamine oxidase and COMT, primarily in the liver.
Personal communication
Stig Thunnel 2004: Used in Swedish porphyria ward.
References
- Scientific articles
- Bohrer H, Olthoff D, Roewer N, Schulte am Esch HCJ. Guideline for application of anesthesia in patients with porphyria. [German]. Anasthesiologie und Intensivmedizin 2002; 43(7-8):485-488. #1211
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