/Most recent revision Febr 14 2004 (Pomp). / Hydrophilic substance similar to endogenous adrenaline. Non-CYP metabolism. No data pointing to CYP/NR interaction.

(To be edited, initial data ST OCT 04) Adrenergic, used parenterally in regional anaesthesia, in severe hypotension and in paroxysmal tachycardia. Nasal and ophtalmic preparations are in use on other indications. Hydrophilic substance with chemical structure similiar to endogenous adrenaline, but lacks one hydroxy-group in the aromatic ring. Oxidative deamination is the predominant metabolic pahway, probably as for endogenous monoamines. Hepatic exposure may exceed the uM range in treatment of severe hypotension, but probably not when used in regional anaesthesia. Elimination half life of the parent compound 2-3 hours. No data pointing to CYP metabolism or other CYP/NR interactions. J Goto et al. Autonomic dysfunction in acute intermittent porphyria. Rinsho Shinkeigaku 1989; 29:774-7. (PMID 2582692).