C01CA07 - Dobutamine |
Not porphyrinogenic |
NP |
Rationale
Non-CYP metabolism. No data pointing to CYP-interaction. Four lists stating non-porphyrinogenicity.
Chemical description
Therapeutic characteristics
Synthetic catecholamine used in acute heart failure due to its inotropic effects on the heart. Given in infusion 0.25-1 g/l.
Metabolism and pharmacokinetics
Metabolized in tissues and in the liver. Conjugated to glucuronic acid and methylated by COMT. Excreted in urine within six hours as glucuronide conjugates.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
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