Monograph
C01EB10 - Adenosine |
Not porphyrinogenic |
NP |
Rationale
Endogenous nucleoside. No relevant CYP metabolism.
Chemical description
Endogenous nucleoside.
Therapeutic characteristics
Used to stop paroxysmal supraventricular tachycardia.
Metabolism and pharmacokinetics
Adenosine is an endogenous nucleoside. Adenosine is rapidly taken up by most types of cells, including cellular elements of the blood (erythrocytes) and vascular endothelium, where it is rapidly degraded by deamination to inosine and subsequently to hypoxanthine. In addition, adenosine also undergoes phosphorylation to adenosine monophosphate (AMP) inside blood cells. Half time in blood less than 10 seconds. Non-CYP metabolism.
Published experience
Adenosine monophosphate has been proposed and used as a therapeutic agent in the acute porphyrias in the late 60s (Wiontzek, bibliographic data only + Oaks)
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Acute intermittent porphyria. Report of a case treated with adenosine 5 phosphoric acid. Dermatologica 1969; 138(1):10-18.
Oaks WW, Schultz J, Fleischmajer R. |
5764297 |
| 2. | [Treatment of acute intermittent prophyria using adenosine monophosphoric acid]. Med Klin 1969; 64(27):1238-1240.
Wiontzek H. |
5799781 |
Tradenames
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Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
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Adenocor, injectievloeistof voor intraveneuze toediening 3 mg/ml · Adenosine Eureco-Pharma, injectievloeistof voor intraveneuze toediening 3 mg/ml · Adenosine Fresenius Kabi 3 mg/ml, oplossing voor injectie in een voorgevulde spuit · Adenosine Hikma 6 mg/2 ml, oplossing voor injectie 
Adenocor 6 mg/2 ml sol. inj. i.v. flac. · Adenosine · Adenosine Fresenius Kabi 3 mg/ml sol. inj. i.v. ser. pr?remplie · Adenosine Hikma 6 mg/2 ml sol. inj. i.v. amp. 
Adenocor · ADENOSCAN 30 mg/10 ml SOLUCION PARA PERFUSION · Adenosina Accord 30 mg/10 ml Solucion Para Perfusion efg · Adenosina Accord 6 mg/2 ml Solucion Inyectable efg · Adenosina Hikma 6 mg/2ml Solucion Inyectable efg · Adenosina Kabi 3 mg/ml Solucion Inyectable en Jeringa Precargada · ATEPODIN 100 mg POLVO Y DISOLVENTE PARA SOLUCION INYECTABLE 
ADENOSINE LIFE MEDICAL 5 mg/ml · ADOZIN 10 mg/2ml 
Adenocor · Adenoscan · Adenosine 
Adenocor · Adenosin Fresenius Kabi · Adenosin Life Medical 
Adenocor · Adenosin Life Medical 
Adenocor · Adenosine Kabi · Adenosinum Delfarma 
Adenocor 
Adenocor · Adenosin Life Medical
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