Monograph
C03CA01 - Furosemide |
Propably not porphyrinogenic |
PNP |
Rationale
(CAVE: under revision)Sulfonamide derivative. Conflicting references, but non-metabolism as well as clinical observations point to non-porphyrinogenicity.
Chemical description
Sulfonamide derivative.
Therapeutic characteristics
Shortacting loop-diuretic.
Metabolism and pharmacokinetics
Primarily excreted by filtration and secretion as unchanged drug. Some liver metabolism may occur. The glucuronide is the most significant metabolite. Non-porphyrinogenic metabolism.
Personal communication
Thunell, patient report (n=2): tolerated. Andersson, patient report (n=9): tolerated.
Published experience
Two non-English publications seem to involve uneventful exposure of two acute porphyria patients (Lopes Montes 2004, Moeschlin 1975).
IPNet drug reports
Uneventful use reported in 47 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Moeschlin S, 1975. PMID 56031.
|
56031 |
| 2. | 2004. PMID 15219077.
Lopes Montes A et al. |
15219077 |
Tradenames
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Furosemide 20 mg tabletten, tabletten · Furosemide 40 mg tabletten, tabletten · Furosemide 500 mg Teva, tabletten · Furosemide Accord 10mg/ml, oplossing voor injectie of infusie · Furosemide Accord 20mg/2ml, oplossing voor injectie of infusie · Furosemide Accord 40mg/4ml, oplossing voor injectie of infusie · Furosemide Accord 50mg/5ml, oplossing voor injectie of infusie · Furosemide Auro 20 mg, tabletten · Furosemide Auro 40 mg, tabletten · Furosemide Aurobindo 40 mg, tabletten · Furosemide CF 10 mg/ml injectievloeistof, oplossing voor injectie (i.v., i.m.) 2 ml en 4 ml · Furosemide CF 20 mg, tabletten · Furosemide CF 40 mg, tabletten · Furosemide Kalceks 10 mg/ml oplossing voor injectie/infusie · Furosemide Sandoz 20 mg/2 ml, oplossing voor injectie 10 mg/ml · Furosemide Sandoz 250 mg/25 ml, concentraat voor oplossing voor intraveneuze infusie 10 mg/ml · Furosemide Sandoz 40 mg, tabletten · Furosemide Sandoz 40 mg/4 ml, oplossing voor injectie 10 mg/ml · Furosemide Teva 20 mg, tabletten · Furosemide Teva 40 mg, tabletten · Furosemide Xiromed 20 mg, tabletten · Furosemide Xiromed 40 mg, tabletten · Lasix 500 mg, tabletten · Lasix 500, tabletten 500 mg · Lasix Retard 60, capsules met gereguleerde afgifte 60 mg 
Furosemide Accord 20 mg/2 ml sol. inj. i.v./i.m. amp. · Furosemide Accord 250 mg/25 ml sol. inj. i.v./i.m. flac. · Furosemide Accord 40 mg/4 ml sol. inj. i.v./i.m. amp. · Furosemide Accord 50 mg/5 ml sol. inj. i.v./i.m. amp. · Furosemide EG 40 mg comp. · Lasix · Lasix 250 mg/25 ml sol. perf. (? diluer) i.v. amp. · Lasix 30 mg Prolongatum 30 mg g?l. · Lasix 40 mg comp. · Lasix 500 mg comp. 
Acuix 40 mg Comprimidos efg · Furosemida · Furosemida Accord 20 mg/2 ml Solucion Inyectable y Para Perfusion efg · Furosemida Accord 250 mg/25 ml Solucion Inyectable y Para Perfusion efg · FUROSEMIDA ALTAN 20mg/2ml SOLUCION INYECTABLE EFG · FUROSEMIDA ALTAN 250mg/ 25ml SOLUCION PARA PERFUSION EFG · FUROSEMIDA APOTEX 40 mg COMPRIMIDOS EFG · Furosemida Aurobindo 40 mg Comprimidos efg · Furosemida Aurovitas 40 mg Comprimidos efg · FUROSEMIDA BEXAL 40 mg COMPRIMIDOS EFG · FUROSEMIDA CINFA 40 mg COMPRIMIDOS EFG · Furosemida Combix 40 mg Comprimidos efg · Furosemida Fresenius Kabi 20 mg/2 ml Solucion Inyectable y Para Perfusion efg · FUROSEMIDA KERN PHARMA 40 mg COMPRIMIDOS EFG · Furosemida Mabo 40 mg Comprimidos efg · Furosemida Normon 40 mg Comprimidos efg · Furosemida Pensa 40 mg Comprimidos efg · Furosemida Pharma Combix 40 mg Comprimidos efg · FUROSEMIDA PHYSAN 20mg/2ml SOLUCI?N INYECTABLE EFG · FUROSEMIDA REIG JOFRE 20 mg/2 ml SOLUCION INYECTABLE EFG · FUROSEMIDA REIG JOFRE 250 mg/25 ml SOLUCION PARA PERFUSION IV EFG · FUROSEMIDA SALA 250 mg / 25 ml SOLUCION PARA PERFUSION EFG · Furosemida Teva 40 mg Comprimidos efg · Furosemida Viatris 40 mg Comprimidos efg · Furosemida vir 40 mg Comprimidos efg · Seguril · SEGURIL 20 mg/2ml SOLUCION INYECTABLE · SEGURIL 40 mg COMPRIMIDOS 
Furosemide · Lasix 
FROSEC 40 mg · FUROSEMID ARENA 40 mg · FUROSEMID BASI 10 mg/ml · FUROSEMID GEMAX PHARMA 40 mg · FUROSEMID HAMELN 10 mg/ml · FUROSEMID LPH 40 mg · FUROSEMID MCC 40 mg · FUROSEMID SLAVIA 40 mg · FUROSEMID ZENTIVA 20 mg/2 ml · FUROSEMID ZENTIVA 40 mg 
Diuresal · Froop · Frusid · Frusol · Furosemide · Lasix 
Diural · Furix · Furosemid 2care4 · Furosemid Accord · Furosemid Basi · Furosemid EQL Pharma · Furosemid Hameln · Furosemid HEXAL · Furosemid Medical Valley · Furosemid Nordic Prime · Furosemide Kalceks · Lasix Retard 
Diural · Furix · Furosemid · Furosemide Kalceks · Lasix Prolongatum · Lasix Retard 
Furosemid · Furosemid Accord · Furosemid hameln · Furosemid Medreg · Furosemide Kabi · Furosemide Kalceks · Furosemide Norameda · Furosemidum Aurovitas · Furosemidum Neupharm · Furosemidum Polfarmex · Furosemidum Polpharma 
Furosemid-ratiopharm · Furosemide · Lasix · Lasix Prolongatum 
Furix · Furosemide Kalceks · Impugan · Lasix Retard 
Furesis · Furosemid hameln · Furosemide Accord · Furosemide Basi · Furosemide Fresenius Kabi · Furosemide Kalceks · Furosemide Norameda · Vesix · Vesix Special 
Furosemide Basi · Furosemide Kalceks · Furosemide Norameda · Furosemide Sopharma · Furosemide Unifarma · Furosemids Olpha 
Entix · Furosemid Accord · Furosemid Belupo · Furosemid Sopharma · Furosemidum Polfarmex · Lasix®
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