Monograph
C03CA04 - Torasemide |
Possibly porphyrinogenic |
PSP |
Rationale
Metabolised by CYP2C9. Torasemide is a sulfonamide congener, drug group often incriminated in porphyric attacks. One reference warns against the drug on grounds of insufficient data.
Chemical description
Sulfonamide congener.
Therapeutic characteristics
Sulfonamide loop-diuretic.
Metabolism and pharmacokinetics
Extensively CYP-metabolized in the liver, CYP2C9 is probably the most important isoenzyme. No data pointing to CYP-induction.
Personal communication
None
Published experience
None
IPNet drug reports
Uneventful use reported in 2 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Torasemide. A review of its pharmacological properties and therapeutic potential.
Friedel HA, Buckley MM. Drugs. 1991 Jan;41(1):81-103. |
1706990 |
| 2. | Torsemide metabolism by CYP2C9 variants and other human CYP2C subfamily enzymes.
Miners JO, Coulter S, Birkett DJ, Goldstein JA. Pharmacogenetics. 2000 Apr;10(3):267-70. |
10803683 |
| 3. | Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism.
Miners JO, Rees DL, Valente L, Veronese ME, Birkett DJ. J Pharmacol Exp Ther. 1995 Mar;272(3):1076-81. |
7891318 |
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Torasemide Sandoz 10 mg comp. · Torasemide Sandoz 20 mg comp. · Torasemide Sandoz 5 mg comp. · Torrem 10 mg comp. · Torrem 2.5 mg comp. 
Dilutol · DILUTOL 5 mg COMPRIMIDOS · DILUTOL HTA 2,5 mg COMPRIMIDOS · ISODIUR 10 mg COMPRIMIDOS · ISODIUR 5 mg COMPRIMIDOS · ISODIUR HTA 2,5 mg COMPRIMIDOS · Sutril · SUTRIL 10 mg COMPRIMIDOS · SUTRIL 5 mg COMPRIMIDOS · SUTRIL HTA 2,5 mg COMPRIMIDOS · SUTRIL NEO 10 mg COMPRIMIDOS DE LIBERACION PROLONGADA · Torasemida · TORASEMIDA ALTER 10 mg COMPRIMIDOS EFG · TORASEMIDA ALTER 5 mg COMPRIMIDOS EFG · TORASEMIDA ARISTO 5 mg COMPRIMIDOS EFG · TORASEMIDA AUROVITAS 10 mg COMPRIMIDOS EFG · TORASEMIDA AUROVITAS 5 mg COMPRIMIDOS EFG · TORASEMIDA CINFA 10 mg COMPRIMIDOS EFG · TORASEMIDA CINFA 5 mg COMPRIMIDOS EFG · TORASEMIDA COMBIX 10 mg COMPRIMIDOS EFG · TORASEMIDA COMBIX 5 mg COMPRIMIDOS EFG · TORASEMIDA NORMON 10 mg COMPRIMIDOS EFG · TORASEMIDA NORMON 5 mg COMPRIMIDOS EFG · Torasemida Sandoz 10 mg Comprimidos efg · Torasemida Sandoz 5 mg Comprimidos efg · TORASEMIDA STADA 10 mg COMPRIMIDOS EFG · TORASEMIDA STADA 5 mg COMPRIMIDOS EFG · Torasemida Stadafarma 10 mg Comprimidos efg · Torasemida Stadafarma 5 mg Comprimidos efg · TORASEMIDA TARBIS 10 mg COMPRIMIDOS EFG · TORASEMIDA TARBIS 5 mg COMPRIMIDOS EFG · TORASEMIDA TEVA 10 mg COMPRIMIDOS EFG · TORASEMIDA TEVA 5 mg COMPRIMIDOS EFG · TORASEMIDA TEVA-RATIO 10 mg COMPRIMIDOS EFG · Torasemida Teva-Ratio 5 mg Comprimidos efg 
Diuremid · Diuresix · Diuretor · Toradiur · Torasemide 
Torasemide · Torem 
Torem 
Astorid · Diured · Diuver · Ebozan · Toradiur · Toramide · Torsemed · Trifas 10 · Trifas 20 · Trifas 200 · Trifas COR 
Torrem 
Torasemid HEXAL · Torasemide HEXAL · Torasemide Teva · Torasemide Zentiva · Trifas 
Diuver®
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