C07FX03 - Metoprolol and Acetylsalicylic Acid |
Not porphyrinogenic |
NP |
Rationale
Two substances generally believed to be safe. Vast clinical experience of non-porphyrinogenicity.
Chemical description
Beta-blocker (metoprolol) + platelet inhibitor: (acetylsalicylic acid).
Metabolism and pharmacokinetics
Metoprolol is metabolized in the liver by CYP2D6.
Personal communication
Metoprolol:
Thunell, patient reports (n=18): tolerated.
Andersson, patient reports (n=26): tolerated.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyria and the dangerous life-threatening drugs.
Eales L. S Afr Med J. 1979 Nov; 56(22):914-7.
|
515871 |
| 2. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 4. | Michael Moore's List
No longer maintained
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| 5. | French List
Centre Français des Porphyries
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| 6. | EPI List
European Porphyria Initiative No longer maintained
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| 7. | South African List
Porphyria South Africa No longer maintained
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Tradenames