C08DA01 - Verapamil

Probably porphyrinogenic

Rationale

Substrate of several CYPs, including 3A4. Potent CYP3A4 inhibitor. Autoactivator of CYP2B6, probably quantitatively insignificant. Some clinical experience of tolerance. Two references state (probable) non-porphyrinogenicity.

Chemical description

Verapamil/norverapamil: Phenylalkylamine derivatives with calcium antagonistic action. Metabolized by CYPs 2C8, 3A4, 3A5, 2C9, 2E1, 1A2, 2B6, 2C19. Inhibitor of CYPs 2C8, 1A2, 2C9, 3A4 (potent) 2D6, 2C19. Autoactivator of CYP 2B6.

Personal communication

Thunell, patient report (n=2): tolerated. Andersson, patient reports: tolerated (n=4).

IPNet drug reports

Uneventful use reported in 4 patients with acute porphyria.

Similar drugs

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References

#	Citation details	PubMed ID
1.	Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases. Kauppinen R, Mustajoki P. Medicine (Baltimore). 1992 Jan; 71(1):1-13.	1549056
Porphyria Drug Lists
2.	French List Centre Français des Porphyries
3.	South African List Porphyria South Africa No longer maintained

Tradenames

Show more details and information about the listed tradenames

Isoptin · Verapamil

Fibrocard · Isoptine · Lodixal

Isoptine · Verapamil

Manidon

Chinopamil · Isoptin · Verapamil

Isoptin · Verapamil

Cordamil · Isoptin · Verapamil

Isoptin

Cordilox · Cordilox MR · Ethimil MR · Half Securon SR · Ranvera MR · Securon · Securon IV · Securon SR · Univer · Vera-Til SR · Verapamil · Verapress MR · Vertab SR 240 · Zolvera