C08DB01 - Diltiazem |
Probably porphyrinogenic |
PRP |
Rationale
Substrate for several CYPs, including 3A4. Potent mechanism-based CYP 3A4 inhibitor.
Chemical description
Benzodiazepine dervative with calcium antagonistic action, metabolized to desmetyl and desacetyl diltiazem. Substrate of CYPs 2C8,2C9, 2D6, 3A4, 3A5, 3A7. Inhibitor of 2C8, 2C9, 2D6. Potent mechanism-based inhibitor of 3A4. Andersson, patient report (n=3): tolerated. James and Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care. South African list: use with care. French list: authorized. Kauppinen and Mustajoki. Prognosis of acute porphyria: Occurrence of acute attacks, precipitating factors,and assocciated diseases. Medicine 1992; 71, 1-13 : tolerated (n=1).
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
Tradenames
Diltiazem 
Diltiazem · Progor · Tildiem 
Angiodrox · Carreldon · Cronodine · Diltiazem · Diltiwas · Dinisor · Doclis · Lacerol · Lacerol cor · Masdil · Tilker · Trumsal · uni-Masdil 
Blocalcin 
Altiazem · Diladel · Diltiazem · Dilzene · Tildiem 
Diltiazem 
Dilzem 
Adizem-SR · Adizem-XL · Angiozem · Angiozem CR · Angitil SR 120 · Angitil SR 180 · Angitil SR 90 · Angitil XL 240 · Angitil XL 300 · Bi-Carzem SR · Bi-Carzem XL · Calcicard CR · Dilcardia SR · Diltiazem · Dilzem SR 120 · Dilzem SR 60 · Dilzem SR 90 · Dilzem XL 120 · Dilzem XL 180 · Dilzem XL 240 · Disogram SR · Horizem SR · Kenzem SR · Optil · Retalzem 60 · Slozem · Tildiem · Tildiem LA · Tildiem LA 200 · Tildiem LA 300 · Tildiem Retard · Uard 120XL · Uard 180XL · Uard 240XL · Uard 300XL · Viazem XL · Zempt · Zemret 180 XL · Zemret 240 XL · Zemret 300 XL · Zemtard 120 XL · Zemtard 180 XL · Zemtard 240 XL · Zemtard 300 XL · Zeyam · Zildil · Zildil SR 
Capizid · Cardil 
Diltiazem · Dilzem 
Dilzem · Oxycardil 
Diltiazem 
Diltiaz · Diltiazem · Tiazac 
Diltiazem · Progor · Tildiem 
Cardil 
Dilzem 
Altiazem · Cardil · Diltiazem 
Diltiazem 
Diltiazem 
Cortiazem · Diltiazem 
Aldizem · Diltiazem · Diltizem-l