C08DB01 - Diltiazem |
Probably porphyrinogenic |
PRP |
Rationale
Substrate for several CYPs, including 3A4. Potent mechanism-based CYP3A4 inhibitor.
Chemical description
Benzodiazepine dervative with calcium antagonistic action, metabolized to desmetyl and desacetyl diltiazem. Substrate of CYPs 2C8, 2C9, 2D6, 3A4, 3A5, 3A7. Inhibitor of 2C8, 2C9, 2D6. Potent mechanism-based inhibitor of 3A4.
Personal communication
Andersson, patient report (n=3): tolerated.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 2. | Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases.
Kauppinen R, Mustajoki P. Medicine (Baltimore). 1992 Jan; 71(1):1-13.
|
1549056 |
| Porphyria Drug Lists | ||
| 3. | French List
Centre Français des Porphyries
|
|
| 4. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 5. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Diltiazem 
Diltiazem · Progor · Tildiem 
bi Tildiem · Diltiazem · Mono Tildiem · Tildiem 
Angiodrox · Carreldon · Cronodine · Diltiazem · Diltiwas · Dinisor · Doclis · Lacerol · Lacerol cor · Masdil · Tilker · Trumsal · uni-Masdil 
Blocalcin 
Altiazem · Diladel · Diltiazem · Dilzene · Tildiem 
Diltiazem 
Dilzem 
Adizem-SR · Adizem-XL · Angiozem · Angiozem CR · Angitil SR 120 · Angitil SR 180 · Angitil SR 90 · Angitil XL 240 · Angitil XL 300 · Bi-Carzem SR · Bi-Carzem XL · Calcicard CR · Dilcardia SR · Diltiazem · Dilzem SR 120 · Dilzem SR 60 · Dilzem SR 90 · Dilzem XL 120 · Dilzem XL 180 · Dilzem XL 240 · Disogram SR · Horizem SR · Kenzem SR · Optil · Retalzem 60 · Slozem · Tildiem · Tildiem LA · Tildiem LA 200 · Tildiem LA 300 · Tildiem Retard · Uard 120XL · Uard 180XL · Uard 240XL · Uard 300XL · Viazem XL · Zempt · Zemret 180 XL · Zemret 240 XL · Zemret 300 XL · Zemtard 120 XL · Zemtard 180 XL · Zemtard 240 XL · Zemtard 300 XL · Zeyam · Zildil · Zildil SR 
Capizid · Cardil · Diltiazemhydrochlorid · Nifrocal 
Altiazem · Angizem · Cardizem · Coramil · Diltiazem · Dilzem · Slozem · Tildiem 
Diladel · Diltiazem · Dilzem 
Dilzem · Oxycardil 
Diltiazem 
Cardizem · Dilacor · Dilcard · Diltahexal · Diltiazem · Dilzem 
Herbesser 
Diltiaz · Diltiazem · Tiazac 
Diltiazem · Progor · Tildiem 
Cardil 
Dilzem 
Altiazem · Cardil · Deltazen · Diltiazem 
Diltiazem 
Diltiazem 
Cortiazem · Diltiazem 
Aldizem 
Aldizem · Diltiazem · Diltizem-l 
Diacordin