Monograph
C09AA01 - Captopril |
Propably not porphyrinogenic |
PNP |
Rationale
Substrate of 2D6. In major parts not metabolised. No data pointing to CYP-induction or MI complex formation.
Risk for gastrointestinal adverse events in the form of nausea, vomiting, diarrhoea and obstipation motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
ACE- inhibitor. 75% excreted in urine of which 50% is unchanged substance and the rest captoprilcystein and disulfide derivatives. Substrate of CYP 2D6. South African list: use with care. French list: authorized.
Therapeutic characteristics
Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are nausea, vomiting, diarrhoea and obstipation.
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria.
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Captopril Accord 12,5 mg, tabletten · Captopril Accord 25 mg, tabletten · Captopril Accord 50 mg, tabletten · Captopril Mylan 25 mg, tabletten · Captopril Mylan 50 mg, tabletten 
Captopril EG 100 mg comp. · Captopril EG 50 mg comp. 
Captopril · CAPTOPRIL ALTER 25 mg COMPRIMIDOS EFG · CAPTOPRIL ARISTO 50 mg COMPRIMIDOS EFG · CAPTOPRIL CINFA 25 mg COMPRIMIDOS EFG · CAPTOPRIL CINFA 50 mg COMPRIMIDOS EFG · CAPTOPRIL MABO 25 mg COMPRIMIDOS EFG · CAPTOPRIL MYLAN 25 mg COMPRIMIDOS EFG · CAPTOPRIL MYLAN 50 mg COMPRIMIDOS EFG · CAPTOPRIL NORMON 100 mg COMPRIMIDOS EFG · CAPTOPRIL NORMON 25 mg COMPRIMIDOS EFG · CAPTOPRIL NORMON 50 mg COMPRIMIDOS EFG · CAPTOPRIL PENSA 12,5 mg COMPRIMIDOS EFG · CAPTOPRIL QUALIGEN 25 mg COMPRIMIDOS · CAPTOPRIL QUALIGEN 50 mg COMPRIMIDOS · Captopril Sandoz 25 mg Comprimidos efg · Captopril Sandoz 50 mg Comprimidos efg · CAPTOPRIL STADA 25 mg COMPRIMIDOS EFG · CAPTOPRIL STADA 50 mg COMPRIMIDOS EFG · CAPTOPRIL TARBIS 50 mg COMPRIMIDOS EFG 
Captopril 
CAPTOPRIL - AC 25 mg · CAPTOPRIL - AC 50 mg · CAPTOPRIL ARENA 25 mg · CAPTOPRIL ARENA 50 mg · CAPTOPRIL LAROPHARM 25 mg · CAPTOPRIL LPH 25 mg · CAPTOPRIL LPH 50 mg · CAPTOPRIL MCC 25 mg · CAPTOPRIL MCC 50 mg · CAPTOPRIL SINTOFARM 25 mg · CAPTOPRIL TERAPIA 25 mg · CAPTOPRIL TERAPIA 50 mg 
Acepril · Capoten · Captomex · Captopril · Ecopace · Kaplon · Noyada · Tensopril 
Captoinhib · Captopril Stada 
Captopril abz · Captopril Viatris · Kaptopril SA 
Captopril Jelfa · Captopril Polfarmex 
Captopril 
Kaptopril Krka 
Katopil® · Zorkaptil®
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