Monograph
C09AA09 - Fosinopril |
Propably not porphyrinogenic |
PNP |
Rationale
No evidence of significant CYP-dependent metabolism. Two references stating (probable) non- porphyrinogenicity.
Risk for gastrointestinal adverse events in the form of nausea, vomiting, diarrhoea, abdominal pain and dyspepsia motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
Hydrolyzed by esterases in the liver to fosinoprilate, an ACE-inhibitor. Of this is 75% excreted in unchanged form by the kidneys, 20-30% as glucuriode conjugate and 1-5% as p-hydroxy metabolite. South African list:use with care. French list: authorized.
Therapeutic characteristics
Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are nausea, vomiting, diarrhoea, abdominal pain and dyspepsia. Other common side effects are musculoskeletal pain, myalgia, fatigue, chest pain and asthenia.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
Tradenames
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Fosinoprilnatrium Aurobindo 10 mg, tabletten · Fosinoprilnatrium Aurobindo 20 mg, tabletten · Fosinoprilnatrium Doc Generici 10 mg, tabletten · Fosinoprilnatrium Doc Generici 20 mg, tabletten · Fosinoprilnatrium Mylan 10 mg, tabletten · Fosinoprilnatrium Mylan 20 mg, tabletten · Fosinoprilnatrium Sandoz 10, tabletten 10 mg · Fosinoprilnatrium Sandoz 20, tabletten 20 mg 
Fosinil 20 mg comp. 
Fosinopril · FOSINOPRIL AUROBINDO 20 mg COMPRIMIDOS EFG · Fosinopril Aurovitas 20 mg Comprimidos efg · FOSITENS 20 mg COMPRIMIDOS 
Eliten · Fosinopril · Fosipres · Tensogard 
MONOPRIL 10 mg · MONOPRIL 20 mg 
Fosinopril · Staril 
Fosinil 
Fosinopril Actavis 
Monopril®
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