C09BA02 - Enalapril and Diuretics |
Probably not porphyrinogenic |
PNP |
Rationale
Enalapril: No evidence of CYP-dependent metabolism. Some clinical experience as well as two references point to non- porphyrinogenicity. Hydrochlorothiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence.
Chemical description
Enalapril: ACE-inhibitor. Hydrolyzed to enalaprilate, otherwise not metabolized. Hydrochlorthiazide: Thiazide diuretic. Eliminated in urine in unchanged form. No observations of CYP interaction.
Personal communication
Enalapril:
Andersson, patient report (n=7) tolerated.
Hydrochlorthiazide:
Thunell, patient report (n=1): tolerated.
Andersson, patient reports (n=10): tolerated.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Drug reference publications | ||
| 1. | Martindale: The complete drug reference. Pharmaceutical Press.
Sweetman SC, editor.
|
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| Porphyria Drug Lists | ||
| 2. | Australian List
Australian Porphyria Association No longer maintained
|
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| 3. | French List
Centre Français des Porphyries
|
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| 4. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Co-Renitec · Enalaprilmaleaat / Hydrochloorthiazide · Enalaprilmaleaat/HCT 
Co-Enalapril · Co-Renitec 
co Renitec · Enalapril Hctz 
Acediur · Acetensil Plus · Baripril · co-Renitec · Crinoretic · Dabonal Plus · Enalapril / Hidroclorotiazida · Enalapril / Hidroclorotiazida Lasa · Enalapril-Hidroclorotiazida · Enalapril/ Hidroclorotiazida · Herten Plus · Hipoartel Plus · Renitecmax 
co-Enalapril · co-Renitec · Ednyt hct · Renitec Plus 
Acesistem · Condiuren · Elektra · Enalapril · Enalapril / Idroclorotiazide · Enalapril e Idroclorotiazide · Enalapril Idroclorotiazide · Enefin · Gentipress · Lanetik · Sinertec · Vasoretic 
Enap · Enap-hl 
Co-Enalapril · Co-Epril · Enalapril HCT · Enalapril-HCT · Epril Plus 
Enalapril · Innozide 
Corodil Comp · Enacecor · Enalapril / Hydrochlorothiazide · Enalapril / Hydrochlorthiazid · Enalapril Hydrochlorthiazid · Enalapril-Hydrochlorthiazid · Lirpalane · Synerpril 
Enalapril / Hydrochlorothiazide · Enalapril comp · Linatil comp · Renitec · Synerpril 
Co-Renitec · Enalapril Comp · Renitec Comp 
Co-Renitec 
Gliotenzide 
Enalapril Maleate/Hctz · Vaseretic 
co-Enalapril · co-Renitec 
Darazíð · Enalapril / Hydrochlorothiazide · Enalapril comp · Enalapril-Hydrochlorthiazid 
Enalapril Comp · Linatil Comp · Renitec Comp 
EnaHEXAL Comp · Enap-H · Enap-HL 
EnaHexal Comp · Enap-H · Enap-HL 
Enalapril/HCT · Enap-H · Enap-HL · Enzix · Prilenap 
Enap-H · Enap-HL 
Anaton · Co-Berlipril · Enalapril / hidroklorotiazid · Enap-h · Enap-HL · Olinapril 
Enap-h