Monograph

C09BA02 - Enalapril and Diuretics

Propably not porphyrinogenic

Rationale

Enalapril: No evidence of CYP-dependent metabolism. Some clinical experience as well as two references point to non- porphyrinogenicity. Hydrochlorothiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence.

Chemical description

Enalapril: ACE-inhibitor. Hydrolyzed to enalaprilate, otherwise not metabolized. Hydrochlorthiazide: Thiazide diuretic. Eliminated in urine in unchanged form. No observations of CYP interaction. Enalapril: Andersson, patient report (n=7) tolerated. South African list: use with care. French list: avoid. Hydrochlorthiazide: South African list: use. French list: authorized. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlorthiazide has been associated with acute attacks of porphyria and is considred unsafe in porphyric patients. EPI-list: sulfonamides are on the unsafe list.

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C09B / C09BA or go back.

Tradenames

This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Show more details and information about the listed tradenames

Co-Renitec 20/12,5 mg tabletten · Co-Renitec 20/12,5 mg, tabletten · Co-Renitec, tabletten 20/12,5 mg · Enalaprilmaleaat/HCT 20/12,5 mg Teva, tabletten · Enalaprilmaleaat/Hydrochloorthiazide 20/12,5, tabletten 20/12,5 mg · Enalaprilmaleaat/Hydrochloorthiazide CF 20/6 mg, tabletten · Enalaprilmaleaat/Hydrochloorthiazide ratiopharm 20 mg/12,5 mg, tabletten · Enalaprilmaleaat/Hydrochloorthiazide Sandoz 20/12,5 mg, tabletten · Enalaprilmaleaat/Hydrochloorthiazide Sandoz 20/12,5, tabletten 20/12,5 mg · Enalaprilmaleaat/hydrochloorthiazide Sandoz 20/6, tabletten 20 mg/6 mg · Enalaprilmaleaat/Hydrochloorthiazide Viatris 20/12,5 mg, tabletten

Co-Enalapril EG 20 mg - 12.5 mg comp. · Co-Renitec 20 mg - 12.5 mg comp.

ACEDIUR 20 mg/12.5mg comprimidos · ACETENSIL PLUS 20 mg/12,5 mg COMPRIMIDOS EFG · Baripril · CO-RENITEC 20 mg/12,5 mg COMPRIMIDOS · CRINORETIC 20 mg/12,5 mg comprimidos · Dabonal Plus · Enalapril / Hidroclorotiazida · ENALAPRIL-HIDROCLOROTIAZIDA BEXAL 20 mg/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/ HIDROCLOROTIAZIDA PENSA 20/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA ABABOR 20 mg/12,5 mg comprimidos EFG · ENALAPRIL/HIDROCLOROTIAZIDA CINFA 20/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA LASA 20/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA LESVI 20 mg/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA NORMON 20 mg/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA QUALIGEN 20 mg/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA SANDOZ 20/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA STADA 20/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA TARBIS 20 mg/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA TECNIGEN 20/12.5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA TEVA 20 mg/12,5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA TEVA-RATIOPHARM 20 mg/ 12, 5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA UR 20/12.5 mg COMPRIMIDOS EFG · ENALAPRIL/HIDROCLOROTIAZIDA VIR 20/12,5 mg COMPRIMIDOS EFG · Herten Plus · HIPOARTEL PLUS 20 mg/12,5 mg COMPRIMIDOS · RENITECMAX 20 mg/ 6 mg COMPRIMIDOS

Acesistem · Condiuren · Elektra · Enalapril e Idroclorotiazide · Enalapril Idroclorotiazide · Enalapril/Idroclorotiazide · Enefin · Gentipress · Lanetik · Sinertec · Vasoretic

ENAP H 10 mg/25 mg · ENAP-HL 10 mg/12,5 mg · ENAP-HL 20 mg/12,5 mg

Enalapril · Innozide

Corodil Comp · Enacecor · Enalapril Hydrochlorthiazid Teva · Enalapril-Hydrochlorthiazid Krka · Enalapril/Hydrochlorothiazide Medical Valley · Enalapril/Hydrochlorthiazid Actavis · Lirpalane · Synerpril

Co-Renitec · Enalapril Comp ratiopharm · Renitec Comp · Renitec Comp Mite

co-Enalapril eg · co-Renitec

Daraz?? · Darazíð · Enalapril comp Alvogen · Enalapril-Hydrochlorthiazid Krka · Enalapril/Hydrochlorothiazide Medical Valley

Enalapril Comp Orion · Enalapril comp ratiopharm · Linatil Comp · Renitec Comp

EnaHexal Comp · Enap-H · Enap-HL

Enalapril/HCT TEVA · Enap-H · Enap-HL · Enzix® · Enzix® duo · Enzix® duo forte · Prilenap H® · Prilenap® HL

Acute Porphyria Drug Database

Monograph