C09BA03 - Lisinopril and Diuretics |
Not porphyrinogenic |
NP |
Rationale
The two pharmacologically active substances lisinopril and hydrochlorothiazide, are not metabolised.
Chemical description
Lisinopril: ACE-inhibitor. Exceted in urine in unchanged form. Hydrochlorthiazide: Thiazide diuretic, sulfonamide congener. Eliminated in urine in unchanged form. Probably no CYP-affinity.
Personal communication
Lisinopril:
Andersson, patient reports (n=7): tolerated.
Hydrochlorthiazide:
Thunell, patient report (n=1): tolerated.
Andersson, patient reports (n=10): tolerated.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | Australian List
Australian Porphyria Association No longer maintained
|
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| 2. | French List
Centre Français des Porphyries
|
|
| 3. | EPI List
European Porphyria Initiative No longer maintained
|
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| 4. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Lisinopril / Hydrochloorthiazide 
Co-Lisinopril · Zestoretic 
Lisinopril Hctz · Zestoretic 
Doneka Plus · Iricil Plus · Lisinopril / Hidroclorotiazida · Lisinopril Hidroclorotiazida · Lisinopril-Hidroclorotiazida · Lisinopril/ Hidroclorotiazida · Prinivil Plus · Tensikey · Zestoretic 
Lisopress hct · Skopryl Plus 
Lisinopril e Idroclorotiazide · Lisinopril Idroclorotiazide · Nalapres · Prinzide · Zestoretic 
Skopryl Plus 
Co-Lisinopril · Lisinopril HCT · Lisitril Comp · Zestoretic 
Carace 10 Plus · Carace 20 Plus · Caralpha · Lisicostad · Lisinopril · Lisoretic · Zestoretic 10 · Zestoretic 20 
Kombinor · Lisinoplus · Lisinopril / Hydrochlorthiazid · Lisinopril-hydrochlorthiazid 
Lisinopril / Hydrochlorthiazid · Lisinopril / Hydroklortiazid · Zestoretic 
Lisinoplus · Lisinopril / Hydroklortiazid · Lisiplus · Zestoretic 
Lisiprol HCT · Skopryl Plus · Toralis 
Prinzide · Zestoretic 
Lisinopril hct · Lisinopril/Hctz · Zestoretic 
Co-Lisinomyl · co-Lisinopril · LISINOPRIL Comp · Zestoretic 
Lisinopril / Hydrochlorothiazide 
Tolirasim 
Iruzid · Lizopril · Skopryl plus 
Amicor · Iruzid · Lizinopril · Optimon Plus · Skopryl plus 
Iruzid · Liten HCT · Lizinopril / hidroklorotiazid · Prinzide · Skopryl HCT 
Skopryl Plus · Tolirasim