Monograph
C09BA05 - Ramipril and Diuretics |
Propably not porphyrinogenic |
PNP |
Rationale
Ramipril: One reference stating non porphyrinogenicity. Hydrochlorthiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence
Chemical description
Ramipril: Alanine derivative which is hydrolyzed in the liver giving rise to the ACE- inhibitor ramiprilate. Also other metabolites are produced. Hydrochlorthiazide: thiazide diuretic, sulfonamide congener. Eliminated in urine in unchanged form. Probably no CYP-affinity. Ramipril: South African list: use with care. Hydrochlorthiazide: South African list: use. French list: authorized. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlorthiazide has been associated with acute attacks of porphyria and is considred unsafe in porphyric patients. EPI-list: sulfonamides on the unsafe list.
Similar drugs
Tradenames
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Prilitaril-HCT 5mg/25 mg tabletten · Ramipril HCT DOC Generici 2,5 mg/12,5 mg, tabletten · Ramipril HCT DOC Generici 5 mg/25 mg, tabletten · Ramipril/Hydrochloorthiazide Aurobindo 5/25 mg, tabletten · Ramipril/Hydrochloorthiazide Sandoz 5/25 mg, tabletten 
Co-Ramipril Sandoz 5 mg - 25 mg comp. · Ramipril/HCTZ Krka 2.5 mg - 12.5 mg comp. · Ramipril/HCTZ Krka 5 mg - 25 mg comp. · Tritazide 5 mg - 25 mg comp. 
Ramipril / Hidroclorotiazida · Ramipril/Hidroclorotiazida Krka 5 mg/25 mg Comprimidos efg · Ramipril/Hidroclorotiazida Stada 2,5 mg/12,5 mg Comprimidos efg · Ramipril/Hidroclorotiazida Stada 5 mg/25 mg Comprimidos efg · Ramipril/Hidroclorotiazida sun 2,5 mg/12,5 mg Comprimidos efg · Ramipril/Hidroclorotiazida sun 5 mg/25 mg Comprimidos efg · RAMIPRIL/HIDROCLOROTIAZIDA TECNIGEN 2,5/12,5 mg COMPRIMIDOS EFG · RAMIPRIL/HIDROCLOROTIAZIDA TECNIGEN 5/25 mgCOMPRIMIDOS EFG 
Herzaplus · Idroquark · Kruplus · Norazide · Prilace · Ramipril e Idroclorotiazide · Ramipril Idroclorotiazide · Triatec hct · Uniprildiur 
HARTIL HCT 5 mg/25mg · TRITACE PLUS 5 mg/25 mg 
Lerimamed · Marilamed · Ramipril/hydrochlorthiazid 1A Farma · Ramipril/hydrochlorthiazid Hexal · Ranid 
Ampril HD · Ampril HL · Polpril Plus · Tritace 2,5 comb · Tritace 5 comb 
Tritazide 
Cardace Comp 
Co-Ramicor · Hartil HCT · Ramimed HCT 
Ampril® HD · Ampril® HL · Corace® Plus · Prilinda® plus · Tenpril duo® · Tritace® comp · Tritace® comp LS · Vivace Plus L® · Vivace Plus®
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