C09BA05 - Ramipril and Diuretics |
Probably Not Porphyrinogenic |
PNP |
Rationale
Ramipril: One reference stating non porphyrinogenicity. Hydrochlorthiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence
Chemical description
Ramipril: Alanine derivative which is hydrolyzed in the liver giving rise to the ACE- inhibitor ramiprilate. Also other metabolites are produced. Hydrochlorthiazide: thiazide diuretic, sulfonamide congener. Eliminated in urine in unchanged form. Probably no CYP-affinity.
Personal communication
Hydrochlorthiazide:
Thunell, patient report (n=1): tolerated.
Andersson, patient reports (n=10): tolerated.
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References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | Australian List
Australian Porphyria Association No longer maintained
|
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| 2. | French List
Centre Français des Porphyries
|
|
| 3. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 4. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Prilitaril-HCT · Ramipril / Hydrochloorthiazide · Ramipril HCT 
Co-Ramipril · Ramipril/HCTZ · Tritazide 
Cotriatec · Ramipril/Hctz 
Imbarix · Ramipril / Hidroclorotiazida 
Ammorro · Hartil hct · Meramyl hct · Ramipril / Indapamide · Ramipril hct · Tritace hct 
Idroquark · Imbaxir · Kruplus · Miprind · Norazide · Prilace · Ramipril e Idroclorotiazide · Ramipril Idroclorotiazide · Triatec hct · Uniprildiur 
Hartil hct · Ramikomb · Tritace Plus 
Co-Ramipril · Ramipril HCT · Ramipril-HCT · Triatec comp 
Marilamed · Ramipril / hydrochlorthiazid · Ranid 
Ramipril / Hydrochlorothiazide · Ramipril / Hydroklortiazid · Triatec · Triatec comp 
Ammorro · Ampril · Ampril HL · Polpril Plus · Ramizek Inda · Tritace 
Altace hct · Ramipril Hctz · Ramipril-Hctz 
Tritazide 
Cardace Comp 
Ampril · Ampril HL · Camimbo · Hartil HCT · Ramimed HCT 
Camimbo · Co-Ramicor · Hartil HCT 
Ampril · Corace · Prilinda · Tenpril · Tritace · Vivace Plus 
Ampril · Ampril HL · Piramil · Piramil HL · Prilen Plus · Ramicomp · Ramipril · Ramzid · Tritazide 
Ampril · Ampril HL · CoRamipril · Piramil · Ramilife HCT · Ramipril · Tritazide 
Amprilan · Medoram Plus · Ramipril · Tritazide