C09BA06 - Quinapril and Diuretics |
Probably not porphyrinogenic |
PNP |
Rationale
Quinapril: No evidence of CYP-dependent metabolism. Hydrochlorthiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence.
Chemical description
Quinapril: HCl-salt of quinapril, which is a prodrug of the metabolite quinaprilate is excreted unchanged by the kidneys. Hydrochlorthiazide: thiazide diuretic, sulfonamide congener. Eliminated in urine in unchanged form. Probably no CYP-affinity.
Personal communication
Hydrochlorthiazide:
Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | Australian List
Australian Porphyria Association No longer maintained
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| 2. | French List
Centre Français des Porphyries
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| 3. | EPI List
European Porphyria Initiative No longer maintained
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| 4. | South African List
Porphyria South Africa No longer maintained
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Tradenames
Quinapril/HCT 
Acuilix · Quinapril Hctz 
Bicetil · Lidaltrin · Quinapril / Hidroclorotiazida 
Accuretic · Quinapril e Idroclorotiazide · Quinapril Idroclorotiazide · Quinazide 
Accuzide · Accuzide Forte · Accuzide Forte Plus 
Accuretic · Quinapril 
Accupro · Quinaplus · Quinapril / Hydrochlorothiazid 
Accuretic 
Quinapril Hctz · Quinapril/Hctz 
Accuzide · Curapril · Quinaplus · Quinapril / Hydrochlorothiazide · Quinapril HCT · Quinapril/HCT 
Kinapril / hidroklorotiazid