C09BA08 - Cilazapril and Diuretics |
Probably not porphyrinogenic |
PNP |
Rationale
Cilazapril: No evidence of significant CYP-dependent metabolism. Occasional observations of tolerance. Two references stating (probable) non-porphyrinogenicity. Hydrochlorthiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence.
Chemical description
Cilazapril: Hydrolyzed to cilazaprilate, a long term ACE-inhibitor. Excreted (90%) in unchanged form by the kidneys. Hydrochlorthiazide: thiazide diuretic. Eliminated in urine in unchanged form. No observations of CYP interaction.
Personal communication
Cilazapril:
Swedish experience (n=2): safe.
Hydrochlorthiazide:
Thunell, patient report (n=1): tolerated.
Andersson, patient reports (n=10): tolerated.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | Australian List
Australian Porphyria Association No longer maintained
|
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| 2. | French List
Centre Français des Porphyries
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| 3. | EPI List
European Porphyria Initiative No longer maintained
|
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| 4. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Co-Inhibace 
Inhibace Plus · Inocar Plus 
Inhibace Plus 
Inibace Plus · Initiss Plus 
Inhibace Plus 
Dynorm Plus · Inhibace · Inhibace Comp · Inibace comp · Vascace comp 
Cazacombi · Inhibace Plus 
Cilazapril / Hydrochlorothiazide · Inhibace Plus 
Cilazapril/Hctz · Inhibace Plus 
Prilazid 
Inhibace Plus