Monograph

C09DA06 - Candesartan and Diuretics

Propably not porphyrinogenic

Rationale

Candesartan: Mainly eliminated in unchanged form, in minor parts metabolised by CYP 2C9. One reference and some clinical observations point to non- porphyrinogenicity. Hydrochlorothiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence.

Chemical description

Candesartan: Angiotensin II receptor antagonist. Mainly eliminated in unchanged form, to a lesser extent metabolized in the liver by 2C9. Less potent inhibitor of CYP 2C9. Hydrochlortiazide:Tiazide diuretic, sulfonamide congener. Eliminated in urine in unchanged form. Probably no CYP-affinity. Candesartan: Thunell, patient reports (n=5): tolerated. Andersson, patient report (n=1): tolerated. French list: autorisÃ© Hydrochlortiazide: South African list: use. French list: autorisÃ©. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlortiazide has been associated with acute attacks of porphyria and is considred unsafe in porphyric patients. EPI-list: sulfonamides are on the unsafe list.

IPNet drug reports

Uneventful use reported in 8 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C09D / C09DA or go back.

Tradenames

This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Show more details and information about the listed tradenames

Atacand Plus 16/12,5, tabletten 16/12,5 mg · Atacand Plus 8/12,5, tabletten 8/12,5 mg · Candesartan / Hydrochlorothiazide · Candesartan cilexetil HCTZ Krka 16 mg/12,5 mg tabletten · Candesartan cilexetil HCTZ Krka 32 mg/12,5 mg tabletten · Candesartan cilexetil HCTZ Krka 32 mg/25 mg tabletten · Candesartan cilexetil HCTZ Krka 8 mg/12,5 mg tabletten

Atacand Plus 16 mg - 12.5 mg comp. · Atacand Plus 32 mg - 12.5 mg comp. · Atacand Plus 32 mg - 25 mg comp. · Atacand Plus 8 mg - 12.5 mg comp. · Candesartan Plus HCT EG 16 mg - 12.5 mg comp. · Candesartan/HCTZ Krka 16 mg - 12.5 mg comp. · Candesartan/HCTZ Krka 32 mg - 12.5 mg comp. · Candesartan/HCTZ Krka 32 mg - 25 mg comp. · Candesartan/HCTZ Krka 8 mg - 12.5 mg comp. · Co-Candesartan Sandoz 16 mg - 12.5 mg comp. · Co-Candesartan Sandoz 32 mg - 12.5 mg comp. · Co-Candesartan Sandoz 8 mg - 12.5 mg comp. · Co-Candesartan Teva 16 mg - 12.5 mg comp. · Co-Candesartan Viatris 16 mg - 12.5 mg comp.

Atacand Plus · ATACAND PLUS 32 mg/12,5 mg COMPRIMIDOS · ATACAND PLUS FORTE 32 mg/25 mg COMPRIMIDOS · BLOPRESS FORTE 32mg/25 mg COMPRIMIDOS · BLOPRESS PLUS 16/12,5 mg COMPRIMIDOS · BLOPRESS PLUS 32 mg/12,5 mg COMPRIMIDOS · Candesartan / Hidroclorotiazida · Candesartan / Hidroclorotiazida Tarbis 16 mg/12.5 mg Comprimidos efg · Candesartan / Hidroclorotiazida Tarbis 32 mg/12.5 mg Comprimidos efg · Candesartan / Hidroclorotiazida Tarbis 32 mg/25 mg Comprimidos efg · Candesartan / Hidroclorotiazida Tarbis 8 mg/12.5 mg Comprimidos efg · Candesartan /Hidroclorotiazida · CANDESARTAN /HIDROCLOROTIAZIDA RATIOMED 16/12,5 mg COMPRIMIDOS EFG · Candesartan Cilexetilo/Hidroclorotiazida Normon 16 mg/12.5 mg Comprimidos efg · Candesartan Cilexetilo/Hidroclorotiazida Normon 32 mg/12.5 mg Comprimidos efg · Candesartan Cilexetilo/Hidroclorotiazida Normon 32 mg/25 mg Comprimidos efg · Candesartan Cilexetilo/Hidroclorotiazida Normon 8 mg/12.5 mg Comprimidos efg · Candesartan Hidroclorotiazida Alter 16 mg/12,5 mg Comprimidos efg · Candesartan Hidroclorotiazida Alter 32 mg/12,5 mg Comprimidos efg · Candesartan Hidroclorotiazida Alter 32 mg/25 mg Comprimidos efg · Candesartan/Hidroclorotiazida Almus 16 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Apotex ag 16/12.5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Apotex ag 32/12.5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Apotex ag 32/25 mg Comprimidos efg · Candesartan/Hidroclorotiazida Aurovitas 16 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Aurovitas 32 mg/12,5 mg Comprimidos efg · CANDESARTAN/HIDROCLOROTIAZIDA AUROVITAS SPAIN 16 mg/12,5 mg COMPRIMIDOS EFG · Candesartan/Hidroclorotiazida Aurovitas Spain 32 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Aurovitas Spain 32 mg/25 mg Comprimidos efg · Candesartan/Hidroclorotiazida Cinfa 16 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Cinfa 32 mg/25 mg Comprimidos efg · Candesartan/Hidroclorotiazida Cinfa 8 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Cinfamed 16 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Cinfamed 32 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Cinfamed 32 mg/25 mg Comprimidos efg · Candesartan/Hidroclorotiazida Combix 16 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Combix 32 mg/ 12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Combix 32 mg/ 25 mg Comprimidos efg · CANDESARTAN/HIDROCLOROTIAZIDA DAVURGAMA 32/12,5 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA FORTE STADA GENERICOS 32 mg/25 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA KERN PHARMA 16 mg/12,5 mg COMPRIMIDOS EFG · Candesartan/Hidroclorotiazida Kern Pharma 32 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Kern Pharma 32 mg/25 mg Comprimidos efg · Candesartan/Hidroclorotiazida Krka 16 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Krka 32 mg/12,5 mg Comprimidos efg · Candesartan/Hidroclorotiazida Krka 32 mg/25 mg Comprimidos efg · Candesartan/Hidroclorotiazida Mylan 32 mg/25 mg Comprimidos efg · CANDESARTAN/HIDROCLOROTIAZIDA RATIOPHARM 32mg/12,5 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA RATIOPHARM 32mg/25 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA SANDOZ 16 mg/12,5 mg COMPRIMIDOS EFG · Candesartan/Hidroclorotiazida Sandoz 32 mg/25 mg Comprimidos efg · CANDESARTAN/HIDROCLOROTIAZIDA STADA 16/12,5 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA STADA GENERICOS 32 mg/12.5 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA TECNIGEN 16/12,5 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA TEVA 16/12,5 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA TEVAPHARMA 32 mg /25 mg COMPRIMIDOS EFG · CANDESARTAN/HIDROCLOROTIAZIDA TEVAPHARMA 32 mg/12,5 mg COMPRIMIDOS EFG · Candesartan/Hidroclorotiazida Viatris 16 mg/12,5 mg Comprimidos efg · Kanpiduo · Karbicombi · KARBICOMBI 16 mg/12,5 mg COMPRIMIDOS EFG · KARBICOMBI 32 mg/12,5 mg COMPRIMIDOS EFG · KARBICOMBI 8 mg/12,5 mg COMPRIMIDOS EFG · Parapres Plus · PARAPRES PLUS 32 mg /12,5 mg COMPRIMIDOS · Parapres Plus Forte

Blopresid · Candesartan e Idroclorotiazide · Forus · Idrotens · Ratacand Plus

CANDESARTAN HCT SWYSSI 16 mg/12,5 mg · CANDESARTAN HCT SWYSSI 8 mg/12,5 mg · CANZENO HCT 16 mg/12,5mg · CANZENO HCT 8 mg/12,5mg · CO-KARBIS 16 mg/2,5 mg · CO-KARBIS 8 mg/2,5 mg · KARBICOMBI 16 mg/12,5 mg · KARBICOMBI 32 mg/12,5 mg · KARBICOMBI 32 mg/25 mg · KARBICOMBI 8 mg/12,5 mg

Atacand Zid 16 mg/12,5 mg · Atacand Zid 32 mg/12,5 mg · Atacand Zid 32mg /25 mg · Atacand Zid 8 mg/12,5 mg · Candemox Comp · Candesartan / Hydrochlorothiazide · Candexil

Atacand Plus · Atacand Plus Mite · Candemox comp · Candesartan / Hydrochlorothiazide

Candepres HCT · Carzap HCT · Casaro HCT · Kanpiduo · Karbicombi

Atacand Plus · Candesartan Plus HCT EG · Candesartan-comp · Candesartan-ratiopharm comp. · Co-Candesartan Viatris

Candpress Comp

Atacand Plus · Candemox Comp · Canderion Comp · Candesartan / Hydrochlorothiazide · Candesartan/Indapamide Krka · Candestad Comp · Candexetil Comp · Caninda

Canocombi · Carzan HCT · Kanpiduo

Acute Porphyria Drug Database

Monograph