Monograph

C09DA06 - Candesartan and Diuretics

Propably not porphyrinogenic

Rationale

Candesartan: Mainly eliminated in unchanged form, in minor parts metabolised by CYP 2C9. One reference and some clinical observations point to non- porphyrinogenicity. Hydrochlorothiazide: Not metabolised. Probably no CYP-affinity. Clinical experience of non-porphyrinogenicity. Conflicting evidence.

Chemical description

Candesartan: Angiotensin II receptor antagonist. Mainly eliminated in unchanged form, to a lesser extent metabolized in the liver by 2C9. Less potent inhibitor of CYP 2C9. Hydrochlortiazide:Tiazide diuretic, sulfonamide congener. Eliminated in urine in unchanged form. Probably no CYP-affinity. Candesartan: Thunell, patient reports (n=5): tolerated. Andersson, patient report (n=1): tolerated. French list: autorisÃ© Hydrochlortiazide: South African list: use. French list: autorisÃ©. Australian list: unsafe associated with attacks. Thunell, patient report (n=1): tolerated. Andersson, patient reports (n=10): tolerated. Martindale: Hydrochlortiazide has been associated with acute attacks of porphyria and is considred unsafe in porphyric patients. EPI-list: sulfonamides are on the unsafe list.

IPNet drug reports

Uneventful use reported in 8 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes C09D / C09DA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Atacand Plus · Atacand Plus 16/12,5, tabletten 16/12,5 mg · Atacand Plus 8/12,5, tabletten 8/12,5 mg · Candesartan / Hydrochlorothiazide · Candesartan cilexetil/Hydrochloorthiazide Teva 16/12,5 mg, tabletten · Candesartan cilexetil/Hydrochloorthiazide Teva 8/12,5 mg, tabletten · Candesartan cilexetil/Hydrochloorthiazide Torrent 16 mg/12,5 mg tabletten · Candesartan cilexetil/Hydrochloorthiazide Torrent 32 mg/12,5 mg tabletten · Candesartan cilexetil/Hydrochloorthiazide Torrent 32 mg/25 mg tabletten · Candesartan cilexetil/Hydrochloorthiazide Torrent 8 mg/12,5 mg tabletten · Candesartan cilexetil/Hydrochloorthiazide Viatris 16 mg/12,5 mg, tabletten · Candesartan cilexetil/Hydrochloorthiazide Viatris 8 mg/12,5 mg, tabletten · Candesartancilexetil/Hydrochloorthiazide Aurobindo 16/12,5 mg, tabletten · Candesartancilexetil/Hydrochloorthiazide Aurobindo 8/12,5 mg, tabletten · Candesartancilexetil/Hydrochloorthiazide Sandoz 16/12,5 mg, tabletten · Candesartan cilexetil HCTZ · Candesartan cilexetil HCTZ Krka 16 mg/12,5 mg tabletten · Candesartan cilexetil HCTZ Krka 32 mg/12,5 mg tabletten · Candesartan cilexetil HCTZ Krka 32 mg/25 mg tabletten · Candesartan cilexetil HCTZ Krka 8 mg/12,5 mg tabletten

Belgium

Atacand Plus · Atacand Plus 16 mg - 12.5 mg comp. · Atacand Plus 32 mg - 12.5 mg comp. · Atacand Plus 32 mg - 25 mg comp. · Atacand Plus 8 mg - 12.5 mg comp. · Candesartan Plus HCT · Candesartan Plus HCT EG 16 mg - 12.5 mg comp. · Candesartan/HCTZ · Candesartan/HCTZ Krka 16 mg - 12.5 mg comp. · Candesartan/HCTZ Krka 32 mg - 12.5 mg comp. · Candesartan/HCTZ Krka 32 mg - 25 mg comp. · Candesartan/HCTZ Krka 8 mg - 12.5 mg comp. · Co-Candesartan · Co-Candesartan Sandoz 16 mg - 12.5 mg comp. · Co-Candesartan Sandoz 32 mg - 12.5 mg comp. · Co-Candesartan Sandoz 8 mg - 12.5 mg comp. · Co-Candesartan Teva 16 mg - 12.5 mg comp. · Co-Candesartan Viatris 16 mg - 12.5 mg comp.

Denmark

Atacand Zid · Atacand Zid 16 mg/12,5 mg · Atacand Zid 32 mg/12,5 mg · Atacand Zid 32mg /25 mg · Atacand Zid 8 mg/12,5 mg · Candemox Comp · Candesartan / Hydrochlorothiazide · Candesartan/Hydrochlorothiazide "Orion" · Candesartancilexetil/Hydrochlorthiazid "Krka" · Candexil

Norway

Atacand Plus · Atacand Plus Mite · Candemox comp · Candesartan / Hydrochlorothiazide · Candesartan/Hydrochlorothiazide Krka

Poland

Candepres HCT · Carzap HCT · Casaro HCT · Karbicombi

Luxembourg

ATACAND PLUS · Candesartan Comp · Candesartan-ratiopharm comp. · Candesartan Plus HCT · Candesartan Plus HCT EG · Candesartan-comp · Candesartan-comp ratiopharm-32/12,5 · Candesartan-comp ratiopharm-32/25 · Co-Candesartan · Co-Candesartan Viatris

Iceland

Candpress Comp

Finland

Atacand Plus · Candemox Comp · Canderion Comp · Candesartan / Hydrochlorothiazide · Candesartan/Hydrochlorothiazide Holsten · Candesartan/Hydrochlorothiazide Krka · Candesartan/Hydrochlorothiazide Orion · Candesartan/Indapamide Krka · Candestad Comp · Candexetil Comp · Caninda

Latvia

Canocombi · Carzan HCT · Kanpiduo

Acute Porphyria Drug Database

Monograph