Monograph
C10AA03 - Pravastatin |
Propably not porphyrinogenic |
PNP |
Rationale
Pravastatin is not a substrate of CYP enzymes.
Chemical description
HMG-CoA reductase inhibitor.
Therapeutic characteristics
Pravastatin is indicated for the treatment of hypercholesterolemia and cardiovascular prevention.
Less common side effects are dyspepsia, abdominal pain, nausea, vomiting, constipation and diarrhoea.
Metabolism and pharmacokinetics
Pravastatin is not a substrate of CYP3A enzymes (Flockhart 2007) and is metabolized by non-P450-dependent pathways (Corsini 1999, Masubuchi 2007) and is also excreted mainly unchanged (Neuvonen 2008). 50 % is bound to plasma proteins and the elimination half-life is 1.5-2 hours.
In vitro studies have shown that pravastatin has no effect on either CYP3A or CYP2B6 (Dickins 2004, Kocarek 2002).
Personal communication
Thunell, patient report (n=1): tolerated.
IPNet drug reports
Uneventful use reported in 4 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | New insights into the pharmacodynamic and pharmacokinetic properties of statins.
Corsini A, Bellosta S, et al. Pharmacol Ther. 1999 Dec;84(3):413-28. |
10665838 |
| 2. | Induction of cytochromes P450.
Dickins M. Curr Top Med Chem. 2004;4(16):1745-66. |
15579106 |
| 3. | Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes.
Kocarek TA, Dahn MSm, et al. Drug Metab Dispos. 2002 Dec;30(12):1400-5. |
12433810 |
| 4. | Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
Masubuchi Y, Horie T. Crit Rev Toxicol. 2007 Jun;37(5):389-412. |
17612953 |
| 5. | Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.
Neuvonen PJ, Backman JT, Niemi M. Clin Pharmacokinet. 2008;47(7):463-74. |
18563955 |
| * | Drug interaction databases | |
| 6. | Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007).
Flockhart DA. |
|
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
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Pravasor 40 mg omhulde tabletten · Pravastatine Na Stada 10 mg, filmomhulde tabletten · Pravastatine Na STADA 20 mg, filmomhulde tabletten · Pravastatine Na STADA 40 mg, filmomhulde tabletten · Pravastatinenatrium 10 mg Pharmachemie, tabletten · Pravastatinenatrium 10 mg TEVA, tabletten · Pravastatinenatrium 20 mg Pharmachemie, tabletten · Pravastatinenatrium 20 mg TEVA, tabletten · Pravastatinenatrium 40 mg Pharmachemie, tabletten · Pravastatinenatrium 40 mg TEVA, tabletten · Pravastatinenatrium Accord 10 mg tabletten · Pravastatinenatrium Accord 20 mg tabletten · Pravastatinenatrium Accord 40 mg tabletten · Pravastatinenatrium Aurobindo 20 mg, tabletten · Pravastatinenatrium Aurobindo 40 mg, tabletten · Pravastatinenatrium DOC Generici 10 mg, tabletten · Pravastatinenatrium DOC Generici 20 mg, tabletten · Pravastatinenatrium DOC Generici 40 mg, tabletten · Pravastatinenatrium ratiopharm 10 mg, tabletten · Pravastatinenatrium ratiopharm 20 mg, tabletten · Pravastatinenatrium ratiopharm 40 mg, tabletten · Pravastatinenatrium Sandoz 10 mg, tabletten · Pravastatinenatrium Sandoz 10, tabletten 10 mg · Pravastatinenatrium Sandoz 20 mg, tabletten · Pravastatinenatrium Sandoz 40 mg, tabletten · Pravastatinenatrium Teva 10 mg, tabletten · Pravastatinenatrium Teva 20 mg, tabletten · Pravastatinenatrium Teva 40 mg, tabletten · Pravastatinenatrium Viatris 10 mg, tabletten · Pravastatinenatrium Viatris 20 mg, tabletten · Pravastatinenatrium Viatris 40 mg, tabletten 
Prareduct 10 mg comp. · Prareduct 20 mg comp. · Prareduct 40 mg comp. · Pravasor 40 mg compr. enr. · Pravastatin AB 20 mg comp. · Pravastatin AB 40 mg comp. · Pravastatine EG 20 mg compr. pellic. · Pravastatine EG 40 mg compr. pellic. · Pravastatine Sandoz 20 mg comp. · Pravastatine Sandoz 40 mg comp. · Pravastatine Teva 20 mg comp. · Pravastatine Teva 40 mg comp. · Pravastatine Viatris 10 mg comp. · Pravastatine Viatris 20 mg comp. · Pravastatine Viatris 40 mg comp. 
BRISTACOL 10 mg COMPRIMIDOS · BRISTACOL 20 mg COMPRIMIDOS · BRISTACOL 40 mg COMPRIMIDOS · LIPLAT 10 mg COMPRIMIDOS · LIPLAT 20 mg COMPRIMIDOS · LIPLAT 40 mg COMPRIMIDOS · MINUSCOL 10 mg COMPRIMIDOS · MINUSCOL 20 mg COMPRIMIDOS · MINUSCOL 40 mg COMPRIMIDOS · PRAREDUCT 20 mg COMPRIMIDOS · PRAREDUCT 40 mg COMPRIMIDOS · Pravastatina · PRAVASTATINA ALMUS 10 mg COMPRIMIDOS EFG · PRAVASTATINA ALMUS 20 mg COMPRIMIDOS EFG · PRAVASTATINA ALMUS 40 mg COMPRIMIDOS EFG · PRAVASTATINA ALTER 20 mg COMPRIMIDOS EFG · PRAVASTATINA ALTER 40 mg COMPRIMIDOS EFG · PRAVASTATINA APOTEX 10 mg COMPRIMIDOS EFG · PRAVASTATINA APOTEX 20 mg COMPRIMIDOS EFG · PRAVASTATINA APOTEX 40 mg COMPRIMIDOS EFG · PRAVASTATINA ARISTO 20 mg COMPRIMIDOS EFG · PRAVASTATINA ARISTO 40 mg COMPRIMIDOS EFG · Pravastatina Aurobindo 10 mg Comprimidos efg · Pravastatina Aurobindo 40 mg Comprimidos efg · Pravastatina Aurovitas 10 mg Comprimidos efg · Pravastatina Aurovitas 20 mg Comprimidos efg · Pravastatina Aurovitas 40 mg Comprimidos efg · PRAVASTATINA CINFAMED 10 mg COMPRIMIDOS EFG · PRAVASTATINA CINFAMED 20 mg COMPRIMIDOS EFG · PRAVASTATINA CINFAMED 40 mg COMPRIMIDOS EFG · PRAVASTATINA CODRAMOL 20 mg COMPRIMIDOS EFG · PRAVASTATINA CODRAMOL 40 mg COMPRIMIDOS EFG · PRAVASTATINA CODRAMOL10 mg COMPRIMIDOS EFG · PRAVASTATINA CUVE 10 mg COMPRIMIDOS EFG · PRAVASTATINA CUVE 20 mg COMPRIMIDOS EFG · PRAVASTATINA CUVE 40 mg COMPRIMIDOS EFG · PRAVASTATINA DAVUR 10 mg COMPRIMIDOS EFG · PRAVASTATINA DAVUR 20 mg COMPRIMIDOS EFG · PRAVASTATINA DAVUR 40 mg COMPRIMIDOS EFG · PRAVASTATINA FARMALIDER 10 mg COMPRIMIDOS EFG · PRAVASTATINA FARMALIDER 20 mg COMPRIMIDOS EFG · PRAVASTATINA FARMALIDER 40 mg COMPRIMIDOS EFG · PRAVASTATINA KERN PHARMA 10 mg COMPRIMIDOS EFG · PRAVASTATINA KERN PHARMA 20 mg COMPRIMIDOS EFG · PRAVASTATINA KERN PHARMA 40 mg COMPRIMIDOS EFG · PRAVASTATINA KORHISPANA 10 mg COMPRIMIDOS EFG · PRAVASTATINA KORHISPANA 20 mg COMPRIMIDOS EFG · PRAVASTATINA KORHISPANA 40 mg COMPRIMIDOS EFG · PRAVASTATINA MABO 10 mg COMPRIMIDOS EFG · PRAVASTATINA MABO 20 mg COMPRIMIDOS EFG · PRAVASTATINA MABO 40 mg COMPRIMIDOS EFG · PRAVASTATINA NORMON 10 mg COMPRIMIDOS EFG · PRAVASTATINA NORMON 20 mg COMPRIMIDOS EFG · PRAVASTATINA NORMON 40 mg COMPRIMIDOS EFG · PRAVASTATINA PHARMA COMBIX 10 mg COMPRIMIDOS EFG · PRAVASTATINA PHARMA COMBIX 20 mg COMPRIMIDOS EFG · PRAVASTATINA PHARMA COMBIX 40 mg COMPRIMIDOS EFG · PRAVASTATINA QUALIGEN 10 mg COMPRIMIDOS EFG · PRAVASTATINA QUALIGEN 20 mg COMPRIMIDOS EFG · PRAVASTATINA SANDOZ 10 mg COMPRIMIDOS EFG · PRAVASTATINA SANDOZ 20 mg COMPRIMIDOS EFG · PRAVASTATINA SANDOZ 40 mg COMPRIMIDOS EFG · Pravastatina Stada 10 mg Comprimidos Recubiertos con Pelicula efg · Pravastatina Stada 20 mg Comprimidos Recubiertos con Pelicula efg · Pravastatina Stada 40 mg Comprimidos Recubiertos con Pelicula efg · PRAVASTATINA SUN 20 mg COMPRIMIDOS EFG · PRAVASTATINA SUN 40 mg COMPRIMIDOS EFG · PRAVASTATINA TARBIS 10 mg COMPRIMIDOS EFG · PRAVASTATINA TARBIS 20 mg COMPRIMIDOS EFG · PRAVASTATINA TARBIS 40 mg COMPRIMIDOS EFG · PRAVASTATINA TECNIGEN 20 mg COMPRIMIDOS EFG · PRAVASTATINA TECNIGEN 40 mg COMPRIMIDOS EFG · PRAVASTATINA TEVA 10 mg COMPRIMIDOS EFG · PRAVASTATINA TEVA 20 mg COMPRIMIDOS EFG · PRAVASTATINA TEVA 40 mg COMPRIMIDOS EFG · PRAVASTATINA TEVA-RATIO 20 mg COMPRIMIDOS EFG · PRAVASTATINA TEVA-RATIO 40 mg COMPRIMIDOS EFG · Pravastatina Viatris 10 mg Comprimidos efg · Pravastatina Viatris 20 mg Comprimidos efg · Pravastatina Viatris 40 mg Comprimidos efg · PRAVASTATINA VIR 40 mg COMPRIMIDOS EFG · PRITADOL 10 mg COMPRIMIDOS · PRITADOL 20 mg COMPRIMIDOS · PRITADOL 40 mg COMPRIMIDOS 
Aplactin · Langiprav · Prasterol · Pravaselect · Pravastatina · Setac · Vasticor 
Lipostat · Pravastatin 
Pravastatin Sandoz · Pravastatin Stada · Pravastatinnatrium Orifarm · Pravastatinnatrium Teva 
Pravastatin Sandoz 
Pravator 
Prareduct-10 · Prareduct-20 · Prareduct-40 · Pravasor · Pravastatine EG 
Pravastatin Orion · Pravastatin Ratiopharm 
PravaCor®
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