Monograph

C10AA03 - Pravastatin

Propably not porphyrinogenic

PNP

Rationale

Pravastatin is not a substrate of CYP enzymes.

Chemical description

HMG-CoA reductase inhibitor.

Therapeutic characteristics

Pravastatin is indicated for the treatment of hypercholesterolemia and cardiovascular prevention. Less common side effects are dyspepsia, abdominal pain, nausea, vomiting, constipation and diarrhoea.

Metabolism and pharmacokinetics

Pravastatin is not a substrate of CYP3A enzymes (Flockhart 2007) and is metabolized by non-P450-dependent pathways (Corsini 1999, Masubuchi 2007) and is also excreted mainly unchanged (Neuvonen 2008). 50 % is bound to plasma proteins and the elimination half-life is 1.5-2 hours. In vitro studies have shown that pravastatin has no effect on either CYP3A or CYP2B6 (Dickins 2004, Kocarek 2002).

Personal communication

Thunell, patient report (n=1): tolerated.

IPNet drug reports

Uneventful use reported in 4 patients with acute porphyria.

References

#	Citation details	PMID
*	Scientific articles
1.	New insights into the pharmacodynamic and pharmacokinetic properties of statins. Corsini A, Bellosta S, et al. Pharmacol Ther. 1999 Dec;84(3):413-28.
2.	Induction of cytochromes P450. Dickins M. Curr Top Med Chem. 2004;4(16):1745-66.	15579106
3.	Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Kocarek TA, Dahn MSm, et al. Drug Metab Dispos. 2002 Dec;30(12):1400-5.	12433810
4.	Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs. Masubuchi Y, Horie T. Crit Rev Toxicol. 2007 Jun;37(5):389-412.	17612953
5.	Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin. Neuvonen PJ, Backman JT, Niemi M. Clin Pharmacokinet. 2008;47(7):463-74.	18563955
*	Drug interaction databases
6.	Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Flockhart DA.

Similar drugs

Explore alternative drugs in similar therapeutic classes C10A / C10AA or go back.

Tradenames and packages

From some sources, we get a list of packages (United Kingdom, Ireland, Estonia). Other sources contain more or less "clean" versions of the trade name (Denmark, Finland, Iceland, Lithuania, Norway). What you see here is the raw data we get from each country, so there will appear to be duplicates. The bold names are the searchable terms. The gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Netherlands

Pravasor · Pravasor 40 mg omhulde tabletten · Pravastatine · Pravastatine Na Stada 10 mg, filmomhulde tabletten · Pravastatine Na STADA 20 mg, filmomhulde tabletten · Pravastatine Na STADA 40 mg, filmomhulde tabletten · Pravastatinenatrium · Pravastatinenatrium 10 mg Pharmachemie, tabletten · Pravastatinenatrium 10 mg TEVA, tabletten · Pravastatinenatrium 20 mg Pharmachemie, tabletten · Pravastatinenatrium 20 mg TEVA, tabletten · Pravastatinenatrium 40 mg Pharmachemie, tabletten · Pravastatinenatrium 40 mg TEVA, tabletten · Pravastatinenatrium Accord 10 mg tabletten · Pravastatinenatrium Accord 20 mg tabletten · Pravastatinenatrium Accord 40 mg tabletten · Pravastatinenatrium Aurobindo 20 mg, tabletten · Pravastatinenatrium Aurobindo 40 mg, tabletten · Pravastatinenatrium DOC Generici 10 mg, tabletten · Pravastatinenatrium DOC Generici 20 mg, tabletten · Pravastatinenatrium DOC Generici 40 mg, tabletten · Pravastatinenatrium ratiopharm 10 mg, tabletten · Pravastatinenatrium ratiopharm 20 mg, tabletten · Pravastatinenatrium ratiopharm 40 mg, tabletten · Pravastatinenatrium Sandoz 10 mg, tabletten · Pravastatinenatrium Sandoz 10, tabletten 10 mg · Pravastatinenatrium Sandoz 20 mg, tabletten · Pravastatinenatrium Sandoz 20, tabletten 20 mg · Pravastatinenatrium Sandoz 40 mg, tabletten · Pravastatinenatrium Sandoz 40, tabletten 40 mg · Pravastatinenatrium Teva 10 mg, tabletten · Pravastatinenatrium Teva 20 mg, tabletten · Pravastatinenatrium Teva 40 mg, tabletten · Pravastatinenatrium Viatris 10 mg, tabletten · Pravastatinenatrium Viatris 20 mg, tabletten · Pravastatinenatrium Viatris 40 mg, tabletten

Belgium

Prareduct · Prareduct 10 mg comp. · Prareduct 20 mg comp. · Prareduct 40 mg comp. · Pravasor · Pravasor 40 mg compr. enr. · Pravastatin · Pravastatin AB 20 mg comp. · Pravastatin AB 40 mg comp. · Pravastatine · Pravastatine EG 20 mg compr. pellic. · Pravastatine EG 40 mg compr. pellic. · Pravastatine Sandoz 20 mg comp. · Pravastatine Sandoz 40 mg comp. · Pravastatine Teva 20 mg comp. · Pravastatine Teva 40 mg comp. · Pravastatine Viatris 10 mg comp. · Pravastatine Viatris 20 mg comp. · Pravastatine Viatris 40 mg comp.

United Kingdom

Lipostat · Lipostat 10mg tablets · Lipostat 20mg tablets · Lipostat 40mg tablets · Pravastatin · Pravastatin 10mg tablets · Pravastatin 20mg tablets · Pravastatin 20mg/5ml oral solution · Pravastatin 20mg/5ml oral solution sugar free · Pravastatin 20mg/5ml oral suspension · Pravastatin 40mg tablets · Pravastatin 40mg/5ml oral solution · Pravastatin 40mg/5ml oral suspension · Pravastatin 5mg oral powder sachets · Pravastatin 5mg/5ml oral solution · Pravastatin 5mg/5ml oral suspension

Denmark

Pravastatin · Pravastatin "Sandoz" · Pravastatin "Stada" · Pravastatinnatrium · Pravastatinnatrium "2care4" · Pravastatinnatrium "Nordic Prime" · Pravastatinnatrium "Orifarm" · Pravastatinnatrium "Teva"

Norway

Pravastatin Sandoz

Poland

Pravator

Luxembourg

PRAREDUCT · PRAREDUCT-10 · PRAREDUCT-20 · PRAREDUCT-40 · Pravasor · Pravastatine · Pravastatine EG

Finland

Pravastatin Orion · Pravastatin Ratiopharm

Serbia

PravaCor · PravaCor®

Acute Porphyria Drug Database

Monograph

References