C10AB02 - Bezafibrate |
Probably not porphyrinogenic |
PNP |
Rationale
Substrate of CYP3A4. Two references stating non-porphyrinogenicity. Occasional clinical experience of non-porphyrinogenicity
Chemical description
Cholesterol lowering clofibrate derivative, dose 600 mg/d. Around 95 % absorbed from the gut. Metabolized by CYP3A4 . No data pointing to CYP-induction.
Personal communication
Thunell, patient report (n=1): tolerated.
Andersson, patient report (n=3): tolerated.
IPNet drug reports
Uneventful use reported in 9 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | French List
Centre Français des Porphyries
|
|
| 2. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Bezalip 
Cedur · Eulitop 
Befizal 
Difaterol · Eulitop 
Bezalip 
Bezalip 
Bezafibrat 
Cedur 
Bezafibrate · Bezagen XL · Bezalip · Bezalip Mono · Fibrazate XL · Liparol 400 XL · Lipozate · Zimbacol XL 
Bezalip 
Bezafibrate · Bezalip 
Bezafibrate · Bezalip · Fibalip 
Zafibral 
Bezafibrate · Bezalip 
Cedur · Eulitop 
Bezalip 
Bezamidin 
Bezagen · Bezalip · Bezalip-mono · Fibrazate · Liparol · Zimbacol 
Bezafibrato 
Bezafibrate