C10AB04 - Gemfibrozil |
Probably not porphyrinogenic |
PNP |
Rationale
Substrate of CYP3A4. No data pointing to CYP-inducing properties. One reference: use with care. Occasional observations of non-porphyrinogenicity.
Chemical description
Fibric acid derivative used (1200 mg/d) in hyperlipidemia. Longacting. Metabolized by CYP3A4; inhibitor of CYPs 1A2 (weak), 2C19, 2C8, 2C9. No data point to CYP-induction.
Personal communication
Thunell, patient report (n=2): tolerated.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Gemfibrozil · Lopid 
Lipur 
Gemfibrozilo · Lopid · Trialmin 
Gemfibrozil · Genlip · Lopid 
Gevilon 
Gemfibrozil · Lopid 
Lopid 
Gemfibrozil · Lopid 
Lopid 
Gemfibrozilo · Lopid · Stolip 
Gemfibrozil · Gemizol · Lipazil · Lopid 
Brozil · Ipolipid · Lipistorol 
Gemfibrozil 
Lopid 
Elmogan 
Emfib · Gemfibrozil · Lopid 
Gemfibrozilo 
Gemfibrozil